2. Vitamin D Related/Nuclear Receptor Others
  3. VD/VDR Drug Intermediate
  4. Previtamin D3

Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism.

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Previtamin D3

Previtamin D3 Chemical Structure

CAS No. : 1173-13-3

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Other Forms of Previtamin D3:

Previtamin D3 Related Antibodies

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Description

Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism[1][2].

In Vitro

Previtamin D3 undergoes temperature-dependent first-order interconversion with vitamin D3 in ethanol, with faster isomerization at higher temperatures[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Previtamin D3 Related Antibodies
In Vivo

Previtamin D3 (0.2 J/cm2; topical skin exposure; single dose) Exposure of vitamin-D-deficient rat skin converts cutaneous 7-dehydrocholesterol to previtamin D3, which does not thermally isomerize to vitamin D3 under low-temperature processing conditions[1].
Previtamin D3 (28-111 μg/1000 g consumed diet; p.o.; 7 doses at 3 to 4 day intervals) exhibits 35% of the antirachitic activity of pure vitamin D3 in rachitic North Holland Blue chicks, with this activity hypothesized to originate exclusively from vitamin D3 formed via in vivo isomerization[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vitamin-D-deficient rats[1]
Dosage: 0.2 J/cm2
Administration: topical skin exposure; single dose
Result: Identified radiolabeled previtamin D3 as the main photoproduct in UV-exposed skin extracts, with no vitamin D3 detected right after irradiation.
Verified previtamin D3 using mass spectrometry and UV spectroscopy, and validated its thermal conversion to vitamin D3 via characteristic spectral changes.
Animal Model: North Holland Blue (1-day-old, mixed sex, weight-homogeneous groups, rachitogenic diet-induced rickets)[2]
Dosage: 28 μg/1000 g consumed diet; 44 μg/1000 g consumed diet; 70 μg/1000 g consumed diet; 111 μg/1000 g consumed diet
Administration: p.o.; 7 doses at 3 to 4 day intervals
Result: Recorded dose-dependent reductions in mean t.m.t.-distance values in chick assays, and displayed an antirachitic activity ratio of 0.35 (95% CI, 0.29-0.42) relative to pure vitamin D3.
Molecular Weight

384.64

Formula

C27H44O
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O[C@@H]1CC(/C=C\C2=CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]23[H])=C(C)CC1
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Purity & Documentation
References
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Previtamin D3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Previtamin D31173-13-3Previtamin D 3Previtamin D-3VD/VDRDrug IntermediateVitamin DVitamin D receptorDrug Iintermediatehuman skinvitamin D3North Holland Blue chickstachysterolricketsvitamin-D binding proteinlumisterol7-dehydrocholesterolrat skinInhibitorinhibitorinhibit

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