Procarbazine

Art. -Nr.: HY-13733A: Data Sheet Handling Instructions
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Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research.

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Procarbazine Chemische Struktur

CAS. Nr. : 671-16-9

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Other In-stock Forms of Procarbazine:

Procarbazine Hydrochloride

Other Forms of Procarbazine:

Procarbazine Hydrochloride In-stock

4 Publications Citing Use of MCE Procarbazine

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research^[1]^[2].

In Vitro

Procarbazine (5 and 20 nM; 1 h) treatment shows cell survival at various concentrarions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	L1210 cells
Concentration:	5 and 20 nM
Incubation Time:	1 hour
Result:	Showed 99.3% and 99.9% survival of cells at 5 mM and 20 mM, respectively.

In Vivo

Procarbazine (intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 d) induces micronuclei in hematopoietic cells, but not increases the lacZ mutant frequency (MF) in bone marrow^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male muta mouse (7-8 weeks old) ^[2]
Dosage:	50 and 150 mg/kg
Administration:	Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 days
Result:	Increased the MN frequency appreciably, and observed micronucleus induction in the peripheral blood at 50 mg/kg.

Klinische Studie

Molekulargewicht

221.30

Formel

C₁₂H₁₉N₃O

CAS. Nr.

671-16-9

SMILES

O=C(NC(C)C)C1=CC=C(CNNC)C=C1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. J M Erikson, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33. [Content Brief]

[2]. T Suzuki, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81. [Content Brief]

Procarbazine Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procarbazine671-16-9DNA Alkylator/Crosslinkeranticancer activityHodgkin's diseaseL1210Inhibitorinhibitorinhibit

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