IFN-alpha 5

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IFN-alpha 5 (IFNA5; IFN-α5), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively^[1]. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia^[2].
IFN-alpha 5 involves in innate immunity, and is one of the genes associated with acute viral bronchiolitis (AVB) caused by respiratory syncytial virus (RSV), determining susceptibility to RSV bronchiolitis^[3]^[4]. The excessively expressed interferon-α (IFN-α) might contribute to the uncontrolled inflammatory responses, causing pathological damage during influenza virus infection. However IFN-alpha 5 is dominantly expressed in respiratory epithelial cells from the patients infected with less pathogenic infectious bronchitis virus (IBV)^[5].

References:

[1]. Zhang SY, et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008 Dec;226:29-40. [Content Brief]

[2]. Raj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15;266(17):11360-5. [Content Brief]

[3]. Hirankarn N, et al. Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus. Tissue Antigens. 2008 Dec;72(6):588-92. [Content Brief]

[4]. Janssen R, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis. 2007 Sep 15;196(6):826-34. [Content Brief]

[5]. Yang L, et al. Diversity of locally produced IFN-α subtypes in human nasopharyngeal epithelial cells and mouse lung tissues during influenza virus infection. Appl Microbiol Biotechnol. 2020 Jul;104(14):6351-6361. [Content Brief]

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IFN-alpha 5 Recombinant Proteins (7)

Species:	Human (2) Mouse (3) Rat (2)
Tag:	His (5) Fc (2)
Source:	HEK293 (5) P. pastoris (2)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P76462

IFN-alpha 5/IFNA5 Protein, Rat (HEK293, His) Interferon alpha-5; Interferon alpha-61; Interferon alpha-G; LeIF G	Rat	HEK293
IFN-alpha 5 (IFNA5), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 5/IFNA5 Protein, Rat (HEK293, His) contains 189 a.a. (M1-E189), produced in HEK293 cells with a C-terminal His-tag.

HY-P76461

IFN-alpha 5/IFNA5 Protein, Mouse (HEK293, His) Interferon alpha-5; Interferon alpha-61; Interferon alpha-G; LeIF G	Mouse	HEK293
IFN-alpha 5 (IFNA5), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 5/IFNA5 Protein, Mouse (HEK293, His) contains 166 a.a. (C24-E189), produced in HEK293 cells with a C-terminal His-tag.

HY-P76460

IFN-alpha 5/IFNA5 Protein, Mouse (P.pastoris, His) Interferon alpha-5; Interferon alpha-61; Interferon alpha-G; LeIF G	Mouse	P. pastoris
IFN-alpha 5 (IFNA5), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 5/IFNA5 Protein, Mouse (P.pastoris, His) contains 168 a.a. (C24-E189), produced in P. pastoris yeast cells with a C-terminal His-tag.

HY-P76462A

IFN-alpha 5/IFNA5 Protein, Rat (HEK293, C-His) IFNA5; interferon alpha family, gene 5;	Rat	HEK293
IFN-alpha 5/IFNA5 Protein, Rat (HEK293, C-His) is the recombinant rat-derived IFN-alpha 5/IFNA5, expressed by HEK293 , with C-6*His labeled tag. The total length of IFN-alpha 5/IFNA5 Protein, Rat (HEK293, C-His) is 166 a.a.,

HY-P75892

IFN-alpha 5/IFNA5 Protein, Human (HEK293, Fc) Interferon alpha-5; IFN-alpha-5; Interferon alpha-G; LeIF G	Human	HEK293
IFN-alpha 5 (IFNA5), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 5/IFNA5 Protein, Human (HEK293, Fc) contains 168 a.a. (L22-E189), produced in HEK293 cells cells with a N-terminal hFc-tag.

HY-P75893

IFN-alpha 5/IFNA5 Protein, Human (P.pastoris, His) Interferon alpha-5; IFN-alpha-5; Interferon alpha-G; LeIF G	Human	P. pastoris
IFN-alpha 5 (IFNA5), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 5/IFNA5 Protein, Human (P.pastoris, His) contains 168 a.a. (L22-E189), produced in P. pastoris yeast cells with a C-terminal His-tag.

HY-P76459

IFN-alpha 5/IFNA5 Protein, Mouse (HEK293, Fc) Interferon alpha-5; Interferon alpha-61; Interferon alpha-G; LeIF G	Mouse	HEK293
IFN-alpha 5 (IFNA5), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 5/IFNA5 Protein, Mouse (HEK293, Fc) contains 189 a.a. (M1-E189), produced in HEK293 cells with a C-terminal hFc-tag.

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IFN-alpha 5

IFN-alpha 5

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IFN-alpha 5 Recombinant Proteins (7)