Psoromic acid (Synonyms: Parellic acid)

Cat. No.: HY-130199 Pureza: 99.9%: Ficha de datos
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Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC₅₀ value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition.

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Psoromic acid Estructura química

No. CAS : 7299-11-8

Tamaño	Precio	Stock	Cantidad
500 μg		En stock	Estimated Time of Arrival: December 31

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Descripciòn

IC₅₀ & Target

IC₅₀: 1.3 µM (RabGGTase)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	IC₅₀	31.6 3 Compound: 3	Antiplasmodial activity against liver stage of Plasmodium berghei ANKA expressing GFP infected in human Huh7.5 cells assessed as reduction in PB18S gene expression after 48 hrs by qRT-PCR analysis Antiplasmodial activity against liver stage of Plasmodium berghei ANKA expressing GFP infected in human Huh7.5 cells assessed as reduction in PB18S gene expression after 48 hrs by qRT-PCR analysis	[PMID: 23806111]
Huh-7	IC₅₀	> 100 3 Compound: 3	Cytotoxicity against human Huh7.5 cells after 24 hrs by Cell-titerGlo luminescence assay Cytotoxicity against human Huh7.5 cells after 24 hrs by Cell-titerGlo luminescence assay	[PMID: 23806111]
Huh-7	IC₅₀	31.6 3 Compound: 3	Antiplasmodial activity against liver stage of Plasmodium berghei ANKA expressing GFP infected in human Huh7.5 cells assessed as reduction in PB18S gene expression after 48 hrs by qRT-PCR analysis Antiplasmodial activity against liver stage of Plasmodium berghei ANKA expressing GFP infected in human Huh7.5 cells assessed as reduction in PB18S gene expression after 48 hrs by qRT-PCR analysis	[PMID: 23806111]
Huh-7	IC₅₀	>100 3 Compound: 3	Cytotoxicity against human Huh7.5 cells after 24 hrs by Cell-titerGlo luminescence assay Cytotoxicity against human Huh7.5 cells after 24 hrs by Cell-titerGlo luminescence assay	[PMID: 23806111]
Huh-7	IC₅₀	> 100 3 Compound: 3	Cytotoxicity against human Huh7.5 cells after 24 hrs by Cell-titerGlo luminescence assay Cytotoxicity against human Huh7.5 cells after 24 hrs by Cell-titerGlo luminescence assay	[PMID: 23806111]
Huh-7	IC₅₀	31.6 3 Compound: 3	Antiplasmodial activity against liver stage of Plasmodium berghei ANKA expressing GFP infected in human Huh7.5 cells assessed as reduction in PB18S gene expression after 48 hrs by qRT-PCR analysis Antiplasmodial activity against liver stage of Plasmodium berghei ANKA expressing GFP infected in human Huh7.5 cells assessed as reduction in PB18S gene expression after 48 hrs by qRT-PCR analysis	[PMID: 23806111]
KB	IC₅₀	31.6 3 Compound: 3	Cytotoxicity against human KB cells after 72 hrs by Alamar Blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar Blue assay	[PMID: 23806111]
KB	IC₅₀	31.6 3 Compound: 3	Cytotoxicity against human KB cells after 72 hrs by Alamar Blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar Blue assay	[PMID: 23806111]
KB	IC₅₀	31.6 3 Compound: 3	Cytotoxicity against human KB cells after 72 hrs by Alamar Blue assay Cytotoxicity against human KB cells after 72 hrs by Alamar Blue assay	[PMID: 23806111]

Peso molecular

358.30

Fòrmula

C₁₈H₁₄O₈

No. CAS

7299-11-8

Appearance

Solid

Color

White to off-white

SMILES

OC(C(C=C1OC)=C(OC(C2=C3C)=C(C(O)=C3)C=O)C(OC2=O)=C1C)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Lichen species Usnea complanata

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 7.17 mg/mL (20.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7910 mL	13.9548 mL	27.9096 mL
5 mM	0.5582 mL	2.7910 mL	5.5819 mL
10 mM	0.2791 mL	1.3955 mL	2.7910 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.9%

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Ficha de datos (277 KB) SDS (252 KB)

COA (257 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91. [Content Brief]

[2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7910 mL	13.9548 mL	27.9096 mL	69.7739 mL
	5 mM	0.5582 mL	2.7910 mL	5.5819 mL	13.9548 mL
	10 mM	0.2791 mL	1.3955 mL	2.7910 mL	6.9774 mL
	15 mM	0.1861 mL	0.9303 mL	1.8606 mL	4.6516 mL
	20 mM	0.1395 mL	0.6977 mL	1.3955 mL	3.4887 mL

Psoromic acid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Psoromic acid7299-11-8Parellic acidOthersInhibitorinhibitorinhibit

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Psoromic acid (Synonyms: Parellic acid)

Psoromic acid Related Antibodies

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