7299-11-8
Chemical Structure
Psoromic acid
Synonym(s): Parellic acid
- CAS. Nr.: 7299-11-8
- Formula:C18H14O8
- Molecular Weight:358.30
IUPAC Name: 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid
InChIKey: FUCWJKJZOHOLEO-UHFFFAOYSA-N
SMILES: OC(C(C=C1OC)=C(OC(C2=C3C)=C(C(O)=C3)C=O)C(OC2=O)=C1C)=O
Biological Activity: Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Psoromic acid | 99.9% | Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition. | ||||||||||||||||||||
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- [1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91. [Content Brief]
- [2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79. [Content Brief]
Keywords
