2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. PTP1B-IN-18

PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research.

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PTP1B-IN-18

PTP1B-IN-18 Estructura química

No. CAS : 2848581-84-8

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Descripciòn

PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research[1].

IC50 & Target

ki: 35.2 μM (PTP1B)[1]
In Vivo

PTP1B-IN-18 (Compound 44; 100 mg/kg; p.o.; single administration) reduces 23% of the blood sugar level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats weighing 200-250 g (type 2 diabetic rat model)[1]
Dosage: 100 mg/kg
Administration: Oral administration; single administration
Result: Showed hypoglycemic effect under physiological conditions.
Peso molecular

469.51

Fòrmula

C26H19N3O4S
No. CAS
SMILES

O=C(NC1=CC=C(C=C1)C(O)=O)CSC2=NC3=C(N2)C=CC(OC4=CC=C5C=CC=CC5=C4)=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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PTP1B-IN-18 Related Classifications

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Keywords:

PTP1B-IN-182848581-84-8Phosphatasehypoglycemictype 2 diabetesbenzimidazole derivativesenzyme inhibitionInhibitorinhibitorinhibit

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Nombre del producto:
PTP1B-IN-18
Cat. No.:
HY-144717
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