Pyrroline-5-carboxylate 

Pyrroline-5-carboxylate is a key intermediate in proline anabolism and catabolism. Pyrroline-5-carboxylate plays important roles in plant defense against pathogen invasion, as well as in redox regulation, nucleotide synthesis and other processes in animal cells^[1][2].

Sodium pyrroline-5-carboxylate (0.3-3.0 mM; 1 hour) activates the pentose phosphate pathway in normal human fibroblasts, LLC-RK1 cells and human erythrocytes^[1].
Sodium pyrroline-5-carboxylate (1 μM-0.5 mM; 1 hour) increases the level of phosphoribosyl pyrophosphate in human red blood cells^[1].
Sodium pyrroline-5-carboxylate (0.5 mM; up to 4 hours) increases the level of PP-ribose-P in serum-starved quiescent human fibroblasts in a time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

113.11

C₅H₇NO₂

2139-03-9

O=C(C1=NCCC1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. PHANG J M. The regulatory functions of proline and pyrroline-5-carboxylic acid. Current topics in cellular regulation, 1985, 25: 91-132.

  [2]. Qamar A, et al. Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens. Front Plant Sci. 2015;6:503. Published 2015 Jul 6.  [Content Brief]