2. Metabolic Enzyme/Protease Epigenetics
  3. 17β-HSD Small Interfering RNA (siRNA)
  4. Rapirosiran

Rapirosiran (ALN-HSD) is a HSD17β13-targeting siRNA. Rapirosiran can be used for the research of metabolic dysfunction-associated steatohepatitis.

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RNA, (Am-sp-(2′-deoxy-2′-fluoro)G-sp-Am-Um-Am-Gm-(3′→3′)-[1-de-β-D-ribofuranosyl-1-[(2S)-2,3-dihydroxypropyl]]m5U-(2′→5′)-Cm-Cm-Am-Um-Gm-Cm-(2′-deoxy-2′-fluoro)A-Am-(2′-deoxy-2′-fluoro)A-Am-Gm-Cm-Am-Um-sp-Um-sp-Cm), complex with RNA (Am-sp-Um-sp-Gm-Cm-Um-Um-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)A-Um-Gm-Gm-Am-Cm-Um-Am-Um-Cm-Um) 3′-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1)

Rapirosiran Chemical Structure

CAS No. : 2755196-97-3

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Rapirosiran Related Antibodies

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Description

Rapirosiran (ALN-HSD) is a HSD17β13-targeting siRNA. Rapirosiran can be used for the research of metabolic dysfunction-associated steatohepatitis[1][2].

In Vitro

Rapirosiran can silence HSD17β13 in the liver, thereby reducing free fatty acid levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rapirosiran Related Antibodies
Essai clinique
Masse moléculaire

16307.22

CAS No.
SMILES

[Rapirosiran]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

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Pureté et documentation
Références
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Rapirosiran Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rapirosiran2755196-97-3ALN-HSD ALN-288996 AD-288996ALN288996ALN 288996ALN-288996AD288996AD 288996AD-28899617β-HSDSmall Interfering RNA (siRNA)17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenaseESC-GalNAc-conjugated agentmetabolic dysfunction-associated steatohepatitisnon-alcoholic steatohepatitishepatic HSD17β13 mRNAHSD17β13NASH patientshealthy adultsInhibitorinhibitorinhibit

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