2. Protéines recombinantes
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. K-Cadherin/Cadherin-6
  7. Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His)

Cadherin-6 Protein, Human (594a.a, HEK293, His), a recombinant human Cadherin-6 produced in HEK293 cells, has a His tag at the N-terminus. Cadherin-6 (CDH6) is a type 2 cadherin, which drives epithelial cells toward a mesenchymal condition (EMT) during embryonic development and it is aberrantly re-activated in cancer.

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Description

Cadherin-6 Protein, Human (594a.a, HEK293, His), a recombinant human Cadherin-6 produced in HEK293 cells, has a His tag at the N-terminus. Cadherin-6 (CDH6) is a type 2 cadherin, which drives epithelial cells toward a mesenchymal condition (EMT) during embryonic development and it is aberrantly re-activated in cancer[1].
Background

Cadherin-6 (CDH6) is a class II cadherin involved in themorphogenesis of central nervous system and kidney. Asmany proteins involved in embryogenesis, CDH6 is aberrantly re-activated in cancer[1].
Species

Human
Source

HEK293
Tag

C-6*His
Accession

P55285-1 (T22-A615)
Gene ID
Molecular Construction
N-term
CDH6 (T22-A615)
Accession # P55285-1
6*His
C-term
Protein Length

Extracellular Domain (with propeptide)
Synonyms
rHuCadherin-6, His; Cadherin-6; Kidney Cadherin; CDH6
AA Sequence

TPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGA

Predicted Molecular Mass
67.1 kDa
Masse moléculaire

Approximately 109 kDa,based on SDS-PAGE under reducing conditions.
Glycosylation
Yes
Pureté

≥ 90%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Instruction de manipulation (2659 KB)
Références

Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His) Related Classifications

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Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His)
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