CDH6 - cadherin 6 Gene

Also Known as CAD6; KCAD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1004

About CDH6

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,193,686-31,329,146 (from NCBI)

This gene has 5 transcripts (splice variants), 263 orthologues and 33 paralogues. Broad expression in kidney (RPKM 6.1), gall bladder (RPKM 4.1) and 17 other tissues.

Summary

This gene encodes a member of the Cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II Cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

CDH6 Products (2)

mRNA Protein Name
NM_001362435.2 NP_001349364.1 cadherin-6 isoform 2 preproprotein
NM_004932.4 NP_004923.1 cadherin-6 isoform 1 preproprotein

CDH6 Protein Structure

Cadherin

Cadherin: Cadherin domain (74 - 149)

Cadherin

Cadherin: Cadherin domain (164 - 258)

Cadherin

Cadherin: Cadherin domain (273 - 357)

Cadherin

Cadherin: Cadherin domain (390 - 479)

Cadherin

Cadherin: Cadherin domain (492 - 589)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (638 - 783)

  • 0
  • 200
  • 400
  • 600
  • 790 a.a.
Protein Preferred Names Protein Names

cadherin-6

  • cadherin 6, type 2, K-cadherin (fetal kidney)

Recombinant CDH6 Proteins

Cat. No. Product Name Accession Purity
HY-P7702 Cadherin-6/KCAD Protein, Human (HEK293, Fc) P55285-1 (T19-A615) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P7703 Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His) P55285-1 (T22-A615) ≥ 90%, as determined by reducing SDS-PAGE.

CDH6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83765 K Cadherin Antibody(YA3564) WB, IHC-P, IF-Tissue Human, Mouse, Rat
HY-P85836 Cadherin Antibody (YA5528) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P86027 Cadherin Antibody (YA5719) IHC-P, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Craniofacial-Deafness-Hand Syndrome

  • CDHS

  • Craniofacial Deafness Hand Syndrome

  • Sommer-Young-Wee-Frye Syndrome

  • Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

  • Craniofacial-Hearing Loss-Hand Syndrome
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990028 Raludotatug Inhibitor 99.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164734 Raludotatug Deruxtecan 99.29% Unkown
HY-RS02339 CDH6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17584 Cdh6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24044 Cdh6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991108 Anti-CDH6/K-Cadherin Antibody Inhibitor 95.45% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CDH6 VGNC VGNC:70974
Mus musculus CDH6 MGD MGI:107435
Canis familiaris CDH6 VGNC VGNC:50872
Bos taurus CDH6 VGNC VGNC:27105
Rattus norvegicus CDH6 RGD RGD:2322
Felis catus CDH6 VGNC VGNC:60685
Others CDH6 NCBI