2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. ADC Antibody Transmembrane Glycoprotein
  4. Raludotatug

Raludotatug is a humanized anti-CDH6 IgG1 monoclonal antibody. Raludotatug has antitumor activity and can be used to synthesize the ADC molecule Raludotatug deruxtecan (HY-164734).

For research use only. We do not sell to patients.

CAS No. : 2610074-56-9

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Based on 1 publication(s) in Google Scholar

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Description

Raludotatug is a humanized anti-CDH6 IgG1 monoclonal antibody. Raludotatug has antitumor activity and can be used to synthesize the ADC molecule Raludotatug deruxtecan (HY-164734)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

CDH6
In Vitro

The ADC molecule Raludotatug deruxtecan (HY-164734) is composed of the humanized anti-CDH6 IgG1 monoclonal antibody Raludotatug, a cleavable GGFG tetrapeptide linker, and the topoisomerase I inhibitor DXd (HY-13631D). Raludotatug deruxtecan can be used for research on tumors such as ovarian cancer and renal cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Raludotatug Related Antibodies
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.702 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Raludotatug]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human CDH6/K-Cadherin, His Tag can bind Raludotatug. The EC50 for this effect is 11.54 ng/mL.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB) SDS-PAGE (99 KB) SEC-HPLC (523 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Raludotatug Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raludotatug2610074-56-9ADC AntibodyTransmembrane GlycoproteinG1-kappaCDH6antineoplasticcancerInhibitorinhibitorinhibit

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Raludotatug
Cat. No.:
HY-P990028
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