Cadherin Antibody (YA5528)

Cat. No.: HY-P85836: Data Sheet User Guide for Antibodies
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Cadherin Antibody (YA5528) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Cadherin.

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사이즈	재고	수량
20 μL	견적 받기 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	견적 받기 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	견적 받기 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	견적 받기

Synthetic products have potential research and development risk.

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Cadherin Antibody (YA5528) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Cadherin.

Host

Mouse

Clonality

Monoclonal

분자량

Observed band size: 130 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P55285 / P22223 / P12830 / P55283

Gene ID

1004 [NCBI] / 1001 [NCBI] / 999 [NCBI] / 1002 [NCBI]

Immunogen

Synthesized peptide derived from human cadherin-1 AA range:800-882 according to Cadherin-1

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1000
WB WB: Western Blot	1:500-2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-500
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:1000-5000

Purity	Protein G	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：P55285: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
P22223: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
P12830: Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques (PubMed:29999492). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production; (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria
P55283: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development

Subcellular Localization：P55285: Cell membrane; Single-pass type I membrane protein
P22223: Cell membrane; Single-pass type I membrane protein
P12830: Cell junction, adherens junction; Cell membrane; Single-pass type I membrane protein; Endosome; Golgi apparatus, trans-Golgi network; Cytoplasm; Cell junction, desmosome

Expression：
Tissue_specificity: P55285: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas
P22223: Expressed in some normal epithelial tissues and in some carcinoma cell lines
P12830: Expressed in granuloma macrophages (at protein level) (PubMed:27760340). Expressed in the skin (at protein level) (PubMed:22294297). Expressed in the liver (PubMed:3263290)
P55283: Expressed mainly in brain but also found in other tissues
Induction: P12830: Induced in the hours following cyclic mechanical strain in keratinocytes (PubMed:31835537). Expression is repressed by MACROD1 (PubMed:17893710)

Subunit：P22223: Interacts with CDCP1 and CTNNB1
P12830: Homodimer; disulfide-linked (PubMed:11856755). Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1.

Synonyms

Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324; Cadherin-2; CDw325; Neural cadherin; N-cadherin1 Publication; CD325; Cadherin-3; Placental cadherin; P-cadherin; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin

각종 서류

User Guide for Antibodies (1077 KB)