CDH4 - cadherin 4 Gene

Homo sapiens

Also known as CAD4; RCAD; R-CAD

Gene ID: 1002 | Gene type: protein coding

About CDH4

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:61,252,261-61,940,617 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 261 orthologues and 33 paralogues. Biased expression in spleen (RPKM 3.2), brain (RPKM 3.1) and 6 other tissues.

Summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of Cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CDH4 Products(3)

mRNA	Protein	Name
NM_001252338.2	NP_001239267.1	cadherin-4 isoform 2
NM_001252339.3	NP_001239268.1	cadherin-4 isoform 3
NM_001794.5	NP_001785.2	cadherin-4 isoform 1 preproprotein

CDH4 Protein Structure

Cadherin_pro

Cadherin

Cadherin_C

0
200
400
600
800
916 a.a.

Protein Preferred Names

Protein Names

cadherin-4

R-cadherin

Recombinant CDH4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77172	R-Cadherin/CDH4 Protein, Human (HEK293, His)	P55283 (H21-A734)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Craniofacial-Deafness-Hand Syndrome

CDHS	Craniofacial Deafness Hand Syndrome
Sommer-Young-Wee-Frye Syndrome	Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss
Craniofacial-Hearing Loss-Hand Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02337	CDH4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDH4	VGNC	VGNC:60683
Rattus norvegicus	CDH4	RGD	RGD:621091
Canis familiaris	CDH4	VGNC	VGNC:49712
Mus musculus	CDH4	MGD	MGI:99218
Bos taurus	CDH4	VGNC	VGNC:27104
Macaca mulatta	CDH4	VGNC	VGNC:70972
Others	CDH4	NCBI