CDH4 - cadherin 4 Gene
Also Known as CAD4; RCAD; R-CAD
Species: Homo sapiens
About CDH4
This gene has 3 transcripts (splice variants), 1 gene allele, 261 orthologues and 33 paralogues. Biased expression in spleen (RPKM 3.2), brain (RPKM 3.1) and 6 other tissues.
Summary
This gene is a classical Cadherin from the Cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular Cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this Cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of Cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of Cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
CDH4 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001252338.2 | NP_001239267.1 | cadherin-4 isoform 2 |
| NM_001252339.3 | NP_001239268.1 | cadherin-4 isoform 3 |
| NM_001794.5 | NP_001785.2 | cadherin-4 isoform 1 preproprotein |
CDH4 Protein Structure
Cadherin_pro: Cadherin prodomain like (30 - 117)
Cadherin: Cadherin domain (176 - 266)
Cadherin: Cadherin domain (282 - 383)
Cadherin: Cadherin domain (398 - 498)
Cadherin: Cadherin domain (514 - 604)
Cadherin_C: Cadherin cytoplasmic region (758 - 912)
- 0
- 200
- 400
- 600
- 800
- 916 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cadherin-4 |
|
Recombinant CDH4 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P77172 | R-Cadherin/CDH4 Protein, Human (HEK293, His) | P55283 (H21-A734) | ≥ 85%, as determined by reducing SDS-PAGE. |
CDH4 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82099 | R Cadherin Antibody (YA1844) | WB, IP | Human, Mouse, Rat |
| HY-P82099A | R Cadherin Antibody (YA1844)(PBS only) | WB, IP | Human, Mouse, Rat |
| HY-P85821 | R Cadherin Antibody (YA5513) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P85836 | Cadherin Antibody (YA5528) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86027 | Cadherin Antibody (YA5719) | IHC-P, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hepatocellular Carcinoma |
|
|
| Craniofacial-Deafness-Hand Syndrome |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS02337 | CDH4 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS18750 | Cdh4 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS25237 | Cdh4 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | CDH4 | VGNC | VGNC:60683 |
| Rattus norvegicus | CDH4 | RGD | RGD:621091 |
| Canis familiaris | CDH4 | VGNC | VGNC:49712 |
| Mus musculus | CDH4 | MGD | MGI:99218 |
| Bos taurus | CDH4 | VGNC | VGNC:27104 |
| Macaca mulatta | CDH4 | VGNC | VGNC:70972 |
| Others | CDH4 | NCBI |
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