ICAM-3/CD50 Protein, Human (HEK293, His-Fc)

The ICAM-3/CD50 protein acts as a ligand for the leukocyte adhesion protein LFA-1 and integrin α-D/β-2, suggesting involvement in cell adhesion. ICAM-3 cooperates with integrin α-L/β-2 to facilitate phagocytosis of apoptotic neutrophils, suggesting a role in immune response regulation and apoptotic cell clearance. ICAM-3/CD50 Protein, Human (HEK293, His-Fc) is the recombinant human-derived ICAM-3/CD50 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of ICAM-3/CD50 Protein, Human (HEK293, His-Fc) is 485 a.a., with molecular weight of 125-135 kDa.

ICAM-3/CD50 Protein serves as a ligand for the leukocyte adhesion proteins LFA-1 (integrin alpha-L/beta-2) and integrin alpha-D/beta-2, implicating its involvement in cellular adhesion processes. When associated with integrin alpha-L/beta-2, ICAM-3 plays a contributory role in apoptotic neutrophil phagocytosis by macrophages, suggesting a potential role in the regulation of immune responses and clearance of apoptotic cells. Additionally, ICAM-3 interacts with moesin/MSN, indicating its participation in protein-protein interactions that may influence cellular signaling or structural organization. The multifaceted interactions of ICAM-3 underscore its significance in the intricate network of cellular adhesion and immune-related processes.

Human

HEK293

C-hFc;C-His

P32942 (M1-H485)

3385  [NCBI]

125-135 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.