2. Gene
  3. ICAM3 - intercellular adhesion molecule 3 Gene

ICAM3 - intercellular adhesion molecule 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as CD50; CDW50; ICAM-R

Gene ID: 3385 | Gene type: protein coding

About ICAM3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,333,776-10,339,624 (from NCBI)

This gene has 10 transcripts (splice variants), 452 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 55.9), spleen (RPKM 28.5) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

ICAM3 Products(7)

mRNA Protein Name
NM_001320605.2 NP_001307534.1 intercellular adhesion molecule 3 isoform 2 precursor
NM_001320606.2 NP_001307535.1 intercellular adhesion molecule 3 isoform 3
NM_001320608.2 NP_001307537.1 intercellular adhesion molecule 3 isoform 4
NM_001395374.1 NP_001382303.1 intercellular adhesion molecule 3 isoform 5
NM_001395375.1 NP_001382304.1 intercellular adhesion molecule 3 isoform 6
NM_001395376.1 NP_001382305.1 intercellular adhesion molecule 3 isoform 7
NM_002162.5 NP_002153.2 intercellular adhesion molecule 3 isoform 1 precursor

ICAM3 Protein Structure

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (31 - 119)

Ig_2

Ig_2: Immunoglobulin domain (130 - 193)

Ig_2

Ig_2: Immunoglobulin domain (317 - 395)

Ig_3

Ig_3: Immunoglobulin domain (404 - 466)

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  • 547 a.a.
Protein Preferred Names Protein Names

intercellular adhesion molecule 3

ICAM-3

Recombinant ICAM3 Proteins

Cat. No. Product Name Accession Purity
HY-P72921 ICAM-3/CD50 Protein, Human (HEK293, His) P32942 (Q30-H485) ≥95%
HY-P74872 ICAM-3/CD50 Protein, Human (HEK293, His-Fc) P32942 (M1-H485) ≥95%

Related Diseases

Diseases Alias
Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms

Relapsing Remitting Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Rrms

Multiple Sclerosis Relapsing-Remitting
Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Polyarteritis Nodosa

Polyarteritis

Periarteritis Nodosa

Pan

Periarteritis

Kussmaul-Maier Disease

Panarteritis Nodosa

Kussmaul Disease

Pan - [Polyarteritis Nodosa]

Polyangiitis

Panangiitis

Arteritis Nodosa
Funisitis
Dengue Shock Syndrome

Dss
Dengue Hemorrhagic Fever

Severe Dengue

Dengue Haemorrhagic Fever

Dhf

Severe Dengue Haemorrhagic Fever

Severe Dengue Fever

Dengue Shock Syndrome
Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm
Human Immunodeficiency Virus Infectious Disease

Hiv Infections
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06514 ICAM3 Human Pre-designed siRNA Set A / Unkown