ICAM3 - intercellular adhesion molecule 3 Gene

Also Known as CD50; CDW50; ICAM-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3385

About ICAM3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,333,776-10,339,624 (from NCBI)

This gene has 10 transcripts (splice variants), 452 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 55.9), spleen (RPKM 28.5) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

ICAM3 Products (7)

mRNA Protein Name
NM_001320605.2 NP_001307534.1 intercellular adhesion molecule 3 isoform 2 precursor
NM_001320606.2 NP_001307535.1 intercellular adhesion molecule 3 isoform 3
NM_001320608.2 NP_001307537.1 intercellular adhesion molecule 3 isoform 4
NM_001395374.1 NP_001382303.1 intercellular adhesion molecule 3 isoform 5
NM_001395375.1 NP_001382304.1 intercellular adhesion molecule 3 isoform 6
NM_001395376.1 NP_001382305.1 intercellular adhesion molecule 3 isoform 7
NM_002162.5 NP_002153.2 intercellular adhesion molecule 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
1448173 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12082081 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ICAM3 Protein Structure

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (31 - 119)

Ig_2

Ig_2: Immunoglobulin domain (130 - 193)

Ig_2

Ig_2: Immunoglobulin domain (317 - 395)

Ig_3

Ig_3: Immunoglobulin domain (404 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 547 a.a.
Protein Preferred Names Protein Names

intercellular adhesion molecule 3

  • ICAM-3

ICAM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ICAM3 P32942 EDDM3B Homo sapiens P56851
Validated Y2H
32296183
Intra
ICAM3 P32942 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
ICAM3 P32942 BRICD5 Homo sapiens Q6PL45-2
Validated Y2H
32296183
Intra
ICAM3 P32942 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
ICAM3 P32942 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
ICAM3 P32942 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ICAM3 Proteins

Cat. No. Product Name Accession Purity
HY-P72921 ICAM-3/CD50 Protein, Human (HEK293, His) P32942 (Q30-H485) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74872 ICAM-3/CD50 Protein, Human (HEK293, His-Fc) P32942 (Q30-H485) ≥ 95%, as determined by reducing SDS-PAGE.

ICAM3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81571 ICAM3 Antibody (YA1316) IHC-P, ICC/IF, FC Human
HY-P83264 ICAM3 Antibody (YA3009) WB, IHC-P, ICC/IF Human
HY-P83264A ICAM3 Antibody (YA3009)(PBS only) WB, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Relapsing-Remitting Multiple Sclerosis

  • Relapsing-Remitting Ms

  • Relapsing Remitting Multiple Sclerosis

  • Multiple Sclerosis, Relapsing-Remitting

  • Rrms

  • Multiple Sclerosis Relapsing-Remitting
Colon Carcinoma In Situ

  • Carcinoma In Situ Of Colon

  • Stage 0 Colonic Carcinoma

  • Stage 0 Carcinoma Of Colon

  • Intraepithelial Neoplasia Of Colon, High Grade

  • Carcinoma In Situ Of Cecum

  • Carcinoma In Situ Of Hepatic Flexure

  • Carcinoma In Situ Of Ileocecal Valve

  • Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Polyarteritis Nodosa

  • Polyarteritis

  • Periarteritis Nodosa

  • Pan

  • Periarteritis

  • Kussmaul-Maier Disease

  • Panarteritis Nodosa

  • Kussmaul Disease

  • Pan - [Polyarteritis Nodosa]

  • Polyangiitis

  • Panangiitis

  • Arteritis Nodosa
Funisitis
Dengue Shock Syndrome

  • Dss
Dengue Hemorrhagic Fever

  • Severe Dengue

  • Dengue Haemorrhagic Fever

  • Dhf

  • Severe Dengue Haemorrhagic Fever

  • Severe Dengue Fever

  • Dengue Shock Syndrome
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Human Immunodeficiency Virus Infectious Disease

  • Hiv Infections
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06514 ICAM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20960 Icam5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990436 Anti-ICAM3/CD50 Antibody Inhibitor / Unkown
HY-P992413 MOR102 Inhibitor / Unkown