2. Cytoskeleton
  3. Integrin
  4. MOR102

MOR102 is a fully human IgG4 monoclonal antibody and an ICAM-1 inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the LFA-1 binding site within ICAM-1 domain 1, blocks ICAM-1/LFA-1 interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis.

For research use only. We do not sell to patients.

MOR102

MOR102 Chemical Structure

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MOR102 Related Antibodies

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Description

MOR102 is a fully human IgG4 monoclonal antibody and an ICAM-1 inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the LFA-1 binding site within ICAM-1 domain 1, blocks ICAM-1/LFA-1 interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis[1][2].

Isotype

Fab-G4-nd
Species Reactivity

Human
In Vitro

MOR102 (0.04-10 μg/mL; 30 min) potently inhibits adhesion of human SKW-3 T-cell leukaemia cells to immobilized recombinant ICAM-1 with an IC50 of 3 nM[1].
MOR102 (0.5-50 μg/mL; 4 days) reduces proliferation of human peripheral blood mononuclear cells in mixed lymphocyte cultures[1].
MOR102 (10 μg/mL; overnight) binds to human HaCaT keratinocytes, with increased binding observed on IFN-γ-stimulated HaCaT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MOR102 Related Antibodies
In Vivo

MOR102 (10 mg/kg; i.p.; every alternate day; 4 weeks from day 22-50 after transplantation) significantly reduces epidermal thickness and inflammatory infiltrate in a psoriasis-SCID mouse model[1].
MOR102 (10 mg/kg; i.p.; every other day; 4 weeks) induces orthokeratotic differentiation, reduces epidermal thickness, and decreases inflammatory infiltrate in human chronic plaque-stage psoriasis skin grafts on SCID mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C.B17 SCID mice (6-8 weeks old) transplanted with human split skin grafts[1]
Dosage: 10 mg/kg
Administration: i.p.; every alternate day; 4 weeks from day 22-50 after transplantation
Result: Reduced mean epidermal thickness to 255 μm, a significant reduction compared to control.
Reduced mean inflammatory infiltrate density to 136 cells per high-power field, a marked reduction compared to PBS-treated controls.
Induced reconstitution of orthokeratotic differentiation of the epidermis, with moderate acanthosis, mild papillomatosis, a web-like corneal layer with mild remaining parakeratosis, and a re-established granular layer.
Demonstrated intense staining of keratinocytes in grafts via immunohistochemistry, confirming targeting of ICAM-1 on keratinocytes.
Animal Model: SCID mice transplanted with human split skin grafts[2]
Dosage: 10 mg/kg
Administration: i.p.; every other day; 4 weeks
Result: Reconstituted orthokeratotic differentiation of the transplanted skin.
Significantly reduced epidermal thickness.
Markedly reduced the inflammatory infiltrate within the graft.
Gene ID

3383  [NCBI]

Accession
Target

ICAM1/CD54
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MOR102 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOR102MOR 102MOR-102IntegrinECV304 bladder carcinoma cellshuman keratinocyteshuman peripheral blood mononuclear cellsinterferon-γHaCaT keratinocytesLFA-1psoriasis-SCID mouse modelchronic plaque-stage psoriasisICAM-1SKW-3 T-cell leukaemia cellsInhibitorinhibitorinhibit

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