1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-2 family (γc-family cytokines)
  5. IL-2R beta/CD122 Protein, Human (HEK293, Fc)

IL-2R beta/CD122 Protein, Human (HEK293, Fc)

Cat. No.: HY-P7784
Handling Instructions

IL-2R beta/CD122 Protein, Human (HEK293, Fc) is a recombinant human CD122 expressed in HEK 293 cells with a C-Fc tag at the C-terminus. IL-2R beta/CD122 Protein is essential for the differentiation and function of T cells and NK cells[1][2].

For research use only. We do not sell to patients.

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50 μg $496 Ask For Quote & Lead Time

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IL-2R beta/CD122 Protein, Human (HEK293, Fc) Related Classifications

  • Technical Parameters

  • Properties

  • Documentation

Species

Human

Source

HEK 293

Accession

P14784 (A27-D239)

Gene ID

3560

Synonyms
rHuCD122, C-Fc; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; CD122
AA Sequence

AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKD-Fctag

Molecular Weight

60-80 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity
Data is not available.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

IL-2/IL-15Rβ (also known as CD122) is an integral part of the receptor complex for both IL-2 and IL-15. IL-2R is a heterotrimeric receptor complex consisting of three distinct subunits: α (CD25, p55), β (CD122, p17), and γ (CD132, p64). The expression of these subunits determines the receptor’s binding affinity. Low-affinity IL-2R, consisting of the α subunit with or without the γ subunit, and cannot internalize a ligand. Intermediate-affinity IL-2R, consisting of the β and γ subunits, and is capable of internalization of bound ligand. High-affinity IL-2R, consisting of α, β, and γ subunits, and capable of internalizing ligands with the highest efficiency[1][2].

Documentation
References
  • Reconstitution Calculator

  • Dilution Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
IL-2R beta/CD122 Protein, Human (HEK293, Fc)
Cat. No.:
HY-P7784
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