2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-2 Receptor
  6. IL-2R beta

IL-2R beta

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IL-2R beta (CD122) is a type I cytokine receptor, and belongs to Type 4 subfamily. IL-2R beta is also a key component of the IL-15 receptor. IL-2R beta binds IL-2 with intermediate affinity, and increases the proportion of CD4+ T lymphocytes[1]. IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2]. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes[3]. Human IL-2R beta consists of extracellular domain (A27-T240), helical domain (I241-I265), and cytoplasmic domain (N266-V551). Human IL-2R beta shares <60% aa sequence identity with mouse and rats. Mouse IL-2R beta shares 81.01% aa sequence identity with rats. IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways[4]. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation[5].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P77594
    IL-2R beta/CD122 Protein, Human (HEK293, His-Avi)

    CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6

    		Human HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.
  • HY-P77883
    IL-2R beta/CD122 Protein, Cynomolgus (HEK293, His)

    CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6

    		Cynomolgus HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus IL-2R beta (A27-D239) with a C-Terminal His tag, which is produced in HEK 293.
  • HY-P70631
    IL-2R beta/CD122 Protein, Human (HEK293, His)

    IL-2R beta; IL-2 R beta; IL-2RB; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; CD122

    		Human HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal 6*His tags, which is produced in HEK293 cells.
  • HY-P71746
    IL-2R beta/CD122 Protein, Mouse (P.pastoris, His)

    Il2rbInterleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; CD antigen CD122

    		Mouse P. pastoris
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Mouse (P.pastoris, His) is a recombinant mouse IL-2R beta (27A-240E) with a N-Terminal His tag, which is produced in P.pastoris.
  • HY-P72549
    IL-2R beta/CD122 Protein, Mouse (HEK293, His)

    Interleukin-2 receptor subunit beta; IL-2RB; p70-75; CD122

    		Mouse HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Mouse (HEK293, His) is a recombinant mouse IL-2R beta (27A-240E) with a C-Terminal 6*His tag, which is produced in HEK 293.
  • HY-P76771
    IL-2R beta/CD122 Protein, Rat (HEK293, His)

    Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122

    		Rat HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rat (HEK293, His) is a recombinant rat IL-2R beta (M1-E239) with a C-Terminal His tag, which is produced in HEK293 cells.
  • HY-P76773
    IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, His)

    Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122

    		Rhesus Macaque HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, His) is a recombinant Rhesus Macaque IL-2R beta (M1-D239) with a C-Terminal His tag, which is produced in HEK293 cells.
  • HY-P78635
    IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His)

    IL2RB; RP5-1170K4.6; CD122; P70-75

    		Canine HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Canine (217a.a, HEK293, His) is a recombinant canine IL-2R beta (217a.a, N30-P246) with a C-Terminal His tag, which is produced in HEK293 cells.
  • HY-P76769
    IL-2R beta/CD122 Protein, Canine (HEK293, Fc)

    Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122

    		Canine HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Canine (HEK293, Fc) is a recombinant canine IL-2R beta (M1-P244) with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P77715
    IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc)

    IL-2RB&IL-2RG; IL-2RG; IL-2R subunit gamma; IL-2R subunit beta; IL-2RB; IL15RB; IL-2 R beta&IL-2 R gamma

    		Human HEK293
    IL-2R beta (CD122) and IL-2Rγ (CD132), type Ⅰ cytokine receptors expressed on T lymphocytes, are receptors for IL-2 (Kd: 1 nM for IL-2R beta approximately). IL-2R beta mediates T cell immune responses. IL-2Rγ mediates inflammatory response
    IL-2Rβ and IL-2Rγ heterodimer binds to IL-2 with intermediate affinity. IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc) is a recombinant human IL-2R beta (A27-D239) and IL-2R gamma (L23-A262) heterodimer complex, with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P72386
    IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi)

    IL-2R beta; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; igh affinity IL-2 receptor subunit beta; CD122

    		Human HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant human extracellular region of biotinylated IL-2R beta (A27-D239) with C-Terminal 6*His tags and an Avi tag, which is produced in HEK293 cells.
  • HY-P76772
    IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, Fc)

    Interleukin-2 receptor subunit beta; IL2RB; High affinity IL-2 receptor subunit beta; CD122

    		Rhesus Macaque HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Rhesus Macaque (HEK293, Fc) is a recombinant Rhesus Macaque IL-2R beta (M1-D239) with a C-Terminal hFc tag, which is produced in HEK293 cells.
  • HY-P7784
    IL-2R beta/CD122 Protein, Human (HEK293, Fc)

    rHuCD122, C-Fc; Interleukin-2 receptor subunit beta; IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; High affinity IL-2 receptor subunit beta; CD122

    		Human HEK293
    IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal Fc tag, which is produced in HEK293 cells.
Cat. No. Product Name Effect Purity