IFN-alpha B/IFNA8 Protein, Human (HEK293)

IFN-alpha B/IFNA8 Protein, synthesized by macrophages, displays potent antiviral activities. It stimulates the production of essential enzymes—a protein kinase and an oligoadenylate synthetase—that are pivotal in cellular defense against viral infections. IFN-alpha B/IFNA8 Protein, Human (HEK293) is the recombinant human-derived IFN-alpha B/IFNA8 protein, expressed by HEK293, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.

IFN-alpha B/IFNA8 Protein, produced by macrophages, exhibits potent antiviral activities. It stimulates the production of two crucial enzymes: a protein kinase and an oligoadenylate synthetase. These enzymes play crucial roles in the cellular defense against viral infections.

Measured in antiviral assays using WISH cells infected with vesicular stomatitisvirus (VSV). The ED₅₀ for this effect is 0.2-2 pg/mL.

Human

HEK293

Tag Free

P32881/NP_002161.2 (N-G&P, C24-E189)

3445  [NCBI]

Full Length of Mature Protein

CDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE

Approximately 26 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. /biology-dictionary/g-361-cell.html  [Content Brief]