IFNA8 - interferon alpha 8 Gene

Also Known as IFN-alphaB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3445

About IFNA8

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:21,409,117-21,410,185 (from NCBI)

This gene has 1 transcript (splice variant), 585 orthologues and 16 paralogues.

Summary

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to act upstream of or within defense response to virus. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

IFNA8 Products (1)

mRNA Protein Name
NM_002170.4 NP_002161.2 interferon alpha-8 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNA8 Protein Structure

Interferon

Interferon: Interferon alpha/beta domain (26 - 186)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

interferon alpha-8

  • IFN-alpha-8

IFNA8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFNA8 P32881 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
IFNA8 P32881 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
IFNA8 P32881 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNA8 Proteins

Cat. No. Product Name Accession Purity
HY-P73860 IFN-alpha B/IFNA8 Protein, Human (HEK293, His) P32881/NP_002161.2 (C24-E189) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73861 IFN-alpha B/IFNA8 Protein, Human (HEK293) P32881/NP_002161.2 (N-G&P, C24-E189) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
St. Louis Encephalitis

  • Saint Louis Encephalitis

  • Neuroinvasive St. Louis Encephalitis Virus Infection

  • Encephalitis, St. Louis

  • Neuroinvasive Saint Louis Encephalitis Virus Infection

  • St. Louis Encephalitis Virus Infection

  • St. Louis Encephalitis Virus Neuroinvasive Disease

  • St. Louis Viral Disease

  • Type C Lethargic Encephalitis

  • Encephalitis Type C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06578 IFNA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22570 Ifna6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others IFNA8 NCBI