IFN-alpha B/IFNA8 Protein, Human (HEK293)
Based on 1 Customer Validation
IFN-alpha B/IFNA8 Protein, synthesized by macrophages, displays potent antiviral activities. It stimulates the production of essential enzymes—a protein kinase and an oligoadenylate synthetase—that are pivotal in cellular defense against viral infections. IFN-alpha B/IFNA8 Protein, Human (HEK293) is the recombinant human-derived IFN-alpha B/IFNA8 protein, expressed by HEK293, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IFN-alpha B/IFNA8 Protein, synthesized by macrophages, displays potent antiviral activities. It stimulates the production of essential enzymes—a protein kinase and an oligoadenylate synthetase—that are pivotal in cellular defense against viral infections. IFN-alpha B/IFNA8 Protein, Human (HEK293) is the recombinant human-derived IFN-alpha B/IFNA8 protein, expressed by HEK293, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.
Background
IFN-alpha B/IFNA8 Protein, produced by macrophages, exhibits potent antiviral activities. It stimulates the production of two crucial enzymes: a protein kinase and an oligoadenylate synthetase. These enzymes play crucial roles in the cellular defense against viral infections.
Verified Bioactivity
Measured in antiviral assays using WISH cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 0.2-2 pg/mL.
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
P32881/NP_002161.2 (N-G&P, C24-E189)
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Molecular Construction
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N-term
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Gly-Pro
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IFNA8 (C24-E189)
Accession # P32881/NP_002161.2 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
IFNA8; IFN-Alpha-8; Interferon Alpha 8; LeIF B; IFN-AlphaB; Interferon Alpha-B''; Interferon Alpha Type 201; Interferon, Alpha 8; Interferon Alpha-B2; Interferon Alpha-B'; Interferon Alpha-8; Interferon 1AA8; Interferon Alpha-B
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AA Sequence
CDLPQTHSLGNRRALILLAQMRRISPFSCLKDRHDFEFPQEEFDDKQFQKAQAISVLHEMIQQTFNLFSTKDSSAALDETLLDEFYIELDQQLNDLESCVMQEVGVIESPLMYEDSILAVRKYFQRITLYLTEKKYSSCAWEVVRAEIMRSFSLSINLQKRLKSKE
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Predicted Molecular Mass
19.6 kDa
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Molecular Weight
Approximately 26 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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