CD31/PECAM-1 Protein, Human (HEK293, Fc)

CD31/PECAM-1 is a cell-cell adhesion protein. CD31/PECAM-1 regulates the activation of the slow hormone receptor BDKRB2 in endothelial cells and the activation of ERK1/2 induced by hypertonic shock and induces susceptibility to atherosclerosis. CD31/PECAM-1 mediates adhesion to endothelial cells and regulates tumor growth by forming new endothelial cell tubes. CD31/PECAM-1 Protein, Human (HEK293, Fc) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-hFc labeled tag.

Platelet endothelial cell adhesion molecule (PECAM1), also known as CD31, is a cell-cell adhesion protein. CD31/PECAM-1 is commonly found in endothelial cells, platelets, macrophages and Kupfer cells, granulocytes, lymphocytes (T cells, B cells, and NK cells), megakaryocytes, and osteoclasts. CD31/PECAM-1 regulates the activation of the slow hormone receptor BDKRB2, the activation of slow hormone and hypertonic shock induced ERK1/2 in endothelial cells, and induces susceptibility to atherosclerosis. CD31/PECAM-1 mediates adhesion to endothelial cells and regulates tumor growth by forming new endothelial cell tubes^{[1][2][3][4][5][6]}.

Human

HEK293

C-hFc

P16284-1 (Q28-K601, S563N)

5175  [NCBI]

Extracellular Domain

QENSFTINSVDMKSLPDWTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKANKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWKK

Approximately 110-130 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.