TrkB Protein, Canine (HEK293, Fc)

TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag.

TrkB protein has a high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation^[1].
TrkB protein is involved in epithelial-mesenchymal transition associated with increased migration and invasion in many cancer cell lines^[3].
Abnormal activation caused by overexpression or fusion of TrkB protein can promote the genesis, progression, and treatment resistance of various types of neurogenic tumors^[5].
Dysregulation of TrkB protein is associated with the pathogenesis of many diseases, such as neurodegenerative diseases, angiogenesis, lung adenocarcinoma, and gastric cancer^[2][3][4].

Canine

HEK293

C-hFc

A0A8C0LGP8/XP_541264.2 (C32-H430)

484147  [NCBI]

Partial

CPTSCKCSASRIWCSDPSPGIVAFPRLEPNSADPENITEIYIANQKRLEIINEDDVEAYAGLKNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQETKSSPETQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNLYWDVGNLVSKHMNETSHMQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYKLVAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVADKSGREH

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Pattwell S S, et al. Neurotrophic receptor tyrosine kinase 2 (NTRK2) alterations in low-grade gliomas: report of a novel gene fusion partner in a Pilocytic astrocytoma and review of the literature[J]. Case Reports in Pathology, 2020, 2020.  [Content Brief]

  [2]. Wang X, et al. A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma[J]. PeerJ, 2019, 7: e7125.  [Content Brief]

  [3]. Pattwell, Siobhan S et al. Oncogenic role of a developmentally regulated NTRK2 splice variant. Science advances vol. 8,40 (2022): eabo6789.  [Content Brief]

  [4]. Dalton J E, et al. The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection[J]. PLoS Pathogens, 2015, 11(2): e1004681.  [Content Brief]

  [5]. Li, Yuehua et al. Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours. The journal of pathology. Clinical research vol. 9,2 (2023): 89-99.  [Content Brief]