2. Recombinant Proteins
  3. CD Antigens
  4. Stem Cell CD Proteins Endothelial cell CD Proteins
  5. VCAM-1/CD106
  6. VCAM-1/CD106 Protein, Mouse (HEK293, His-Fc)

VCAM-1 protein is a member of the immunoglobulin superfamily.It can act as a regulator of capillary formation and liver fibrosis, and can promote liver fibrosis.VCAM-1 Protein plays an important role in immune response and inflammatory response.VCAM-1/CD106 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived VCAM-1/CD106 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

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  • Descripciòn

Descripciòn

VCAM-1 protein is a member of the immunoglobulin superfamily.It can act as a regulator of capillary formation and liver fibrosis, and can promote liver fibrosis.VCAM-1 Protein plays an important role in immune response and inflammatory response.VCAM-1/CD106 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived VCAM-1/CD106 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.
Background

VCAM-1 protein supports leukocyte adhesion by binding to α4β1 integrin and is crucial for the recruitment of monocytes and lymphocytes during inflammation[1][5].
VCAM-1 Protein is a regulator of capillary formation and hepatic fibrosis in liver sinusoidal endothelial cells (LSECs). VCAM-1 Protein can activate the Yes-associated protein 1 pathway and induce fibrosis phenotypes in HSCs[2].
VCAM-1 Protein causes persistent inflammation by inhibiting effective T cell apoptosis[3].
VCAM-1 protein causes persistent inflammation by inhibiting the apoptosis of effector T cells[3].
VCAM-1 protein plays an important role in regulating immune response and inflammatory response to viral infection[4].
VCAM-1 Protein is necessary for smooth muscle cell migration. Targeting VCAM-1 expression can effectively prevent and treat atherosclerosis and restenosis[5].
Species

Mouse
Source

HEK293
Tag

C-hFc;C-His
Accession

Q3UPN1 (M1-E698)
Gene ID
Molecular Construction
N-term
VCAM-1 (M1-E698)
Accession # Q3UPN1
hFc-His
C-term
Protein Length

Partial
Synonyms
Vascular Cell Adhesion Protein 1; VCAM-1; INCAM-100; CD106; L1CAM
AA Sequence

MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKNYFSPE

Predicted Molecular Mass
102 kDa
Peso molecular

Approximately 110-120 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Glycosylation
Yes
Pureza

≥ 90%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentación
Instrucciones de manejo (2659 KB)

VCAM-1/CD106 Protein, Mouse (HEK293, His-Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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