rel-Paroxetine-d4 hydrochloride
rel-Paroxetine-d4 (rel-BRL29060-d4) hydrochloride is an isotope-labeled rel-Paroxetine hydrochloride.
For research use only. We do not sell to patients.
- CAS No.: 1217683-35-6
- Formula: C19H17D4ClFNO3
- Molecular Weight:369.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Collagen-induced arthritis (CIA) model in rats (around 14-day-old)[2]
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Dosage:15 mg/kg
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Administration:Oral gavage; once daily; 15 days
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Result:Helped CIA rats to restore more body weight.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217683-35-6
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Unlabeled Cas 130855-15-1
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Molecular Weight 369.85
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Formula C19H17D4ClFNO3
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SMILES
FC(C([2H])=C1[2H])=C([2H])C([2H])=C1[C@H](CCNC2)[C@@H]2COC3=CC=C(OCO4)C4=C3.Cl
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Synonyms
rel-BRL29060-d4 hydrochloride; rel-BRL29060A-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
[2]. Wang Q, et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28;7:45364. [Content Brief]
[3]. Liu RP, et al. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation. 2014 Mar 12;11:47. [Content Brief]
[4]. Hwang S, et al. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. Eur J Pharmacol. 2021 Dec 5;912:174567. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
rel-Paroxetine-d4 hydrochloride Related Classifications
HY-151216S Related Classifications
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