(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

Cat. No.: HY-138551A Purity: 95.14%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC ligand, it can be used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure

CAS No. : 2417370-89-7

Size	Price	Stock	Quantity
Solid or liquid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 258	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 258	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

938.15

Formula

C₄₁H₆₂F₃N₅O₁₀S₃

CAS No.

2417370-89-7

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(N(C[C@@H]1OC(OC(C)C(C)S[S](C)(=O)=O)=O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCCCN)=O.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (106.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0659 mL	5.3296 mL	10.6593 mL
5 mM	0.2132 mL	1.0659 mL	2.1319 mL
10 mM	0.1066 mL	0.5330 mL	1.0659 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.14%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (251 KB) HNMR (179 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0659 mL	5.3296 mL	10.6593 mL	26.6482 mL
	5 mM	0.2132 mL	1.0659 mL	2.1319 mL	5.3296 mL
	10 mM	0.1066 mL	0.5330 mL	1.0659 mL	2.6648 mL
	15 mM	0.0711 mL	0.3553 mL	0.7106 mL	1.7765 mL
	20 mM	0.0533 mL	0.2665 mL	0.5330 mL	1.3324 mL
	25 mM	0.0426 mL	0.2132 mL	0.4264 mL	1.0659 mL
	30 mM	0.0355 mL	0.1777 mL	0.3553 mL	0.8883 mL
	40 mM	0.0266 mL	0.1332 mL	0.2665 mL	0.6662 mL
	50 mM	0.0213 mL	0.1066 mL	0.2132 mL	0.5330 mL
	60 mM	0.0178 mL	0.0888 mL	0.1777 mL	0.4441 mL
	80 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.3331 mL
	100 mM	0.0107 mL	0.0533 mL	0.1066 mL	0.2665 mL