Salcaprozate-d₄ sodium (Synonyms: SNAC-d4 sodium)

製品番号: HY-114299S 純度: 99.72%: Data Sheet SDS COA 取扱説明書
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Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium). Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.

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Salcaprozate-d₄ sodium 構造式

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1133	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1133	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solid
1 mg	$410	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1030	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	$1650	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
25 mg	$3300	お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of Salcaprozate-d₄ sodium:

Salcaprozate sodium 在庫あり
8-(2-Hydroxybenzamido)octanoic acid-d₄ お問い合わせ

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製品説明

Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium)^[1]. Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation^[2]^[3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL^[4].
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats^[4].
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident^[2].
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

305.34

分子式

C₁₅H₁₆D₄NNaO₄

Unlabeled CAS

203787-91-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CCCCCCCNC(C1=C([2H])C([2H])=C([2H])C([2H])=C1O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (327.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2750 mL	16.3752 mL	32.7504 mL
5 mM	0.6550 mL	3.2750 mL	6.5501 mL
10 mM	0.3275 mL	1.6375 mL	3.2750 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.72%

Select Batch:

データシート (271 KB) SDS (393 KB)

COA (244 KB) HNMR (148 KB) RP-HPLC (250 KB) LCMS (108 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Riley MGI, et, al. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats. Int J Toxicol. Jul-Aug 2009; 28(4):278-93. [Content Brief]

[3]. Twarog C, et, al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C 10). Pharmaceutics. 2019 Feb 13; 11(2):78. [Content Brief]

[4]. Li Y, et, al. Impact of Sodium N-[8-(2-Hydroxybenzoyl)amino]-caprylate on Intestinal Permeability for Notoginsenoside R1 and Salvianolic Acids in Caco-2 Cells Transport and Rat Pharmacokinetics. Molecules. 2018 Nov 16; 23(11):2990. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2750 mL	16.3752 mL	32.7504 mL	81.8759 mL
	5 mM	0.6550 mL	3.2750 mL	6.5501 mL	16.3752 mL
	10 mM	0.3275 mL	1.6375 mL	3.2750 mL	8.1876 mL
	15 mM	0.2183 mL	1.0917 mL	2.1834 mL	5.4584 mL
	20 mM	0.1638 mL	0.8188 mL	1.6375 mL	4.0938 mL
	25 mM	0.1310 mL	0.6550 mL	1.3100 mL	3.2750 mL
	30 mM	0.1092 mL	0.5458 mL	1.0917 mL	2.7292 mL
	40 mM	0.0819 mL	0.4094 mL	0.8188 mL	2.0469 mL
	50 mM	0.0655 mL	0.3275 mL	0.6550 mL	1.6375 mL
	60 mM	0.0546 mL	0.2729 mL	0.5458 mL	1.3646 mL
	80 mM	0.0409 mL	0.2047 mL	0.4094 mL	1.0234 mL
	100 mM	0.0328 mL	0.1638 mL	0.3275 mL	0.8188 mL

Salcaprozate-d₄ sodium Related Classifications

Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Salcaprozate-d₄SNAC-d4Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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Salcaprozate-d4 sodium (Synonyms: SNAC-d4 sodium)

Other Forms of Salcaprozate-d4 sodium:

Salcaprozate-d4 sodium 関連抗体