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Salcaprozate sodium (Synonyms: SNAC)

Cat. No.: HY-114299
Handling Instructions

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.

For research use only. We do not sell to patients.

Salcaprozate sodium Chemical Structure

Salcaprozate sodium Chemical Structure

CAS No. : 203787-91-1

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Based on 1 publication(s) in Google Scholar

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Description

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].

In Vitro

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL[3].
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats[3].
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident[1].
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (6-7 weeks)[1]
Dosage: 2000 mg/kg/d
Administration: Oral gavage for 13 weeks
Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.
Clinical Trial
Molecular Weight

301.31

Formula

C₁₅H₂₀NNaO₄

CAS No.

203787-91-1

SMILES

O=C(O[Na])CCCCCCCNC(C1=CC=CC=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

SalcaprozateSNACOthersabsorptionpromoterdeliverytranscellularpermeationacrosslipophilicitynon-covalentmacromoleculecomplexationInhibitorinhibitorinhibit

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Product Name:
Salcaprozate sodium
Cat. No.:
HY-114299
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