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Salcaprozate sodium  (Synonyms: SNAC)

Cat. No.: HY-114299 Purity: 98.85%
COA Handling Instructions

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.

For research use only. We do not sell to patients.

Salcaprozate sodium Chemical Structure

Salcaprozate sodium Chemical Structure

CAS No. : 203787-91-1

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Description

Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].

In Vitro

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL[3].
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats[3].
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident[1].
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (6-7 weeks)[1]
Dosage: 2000 mg/kg/d
Administration: Oral gavage for 13 weeks
Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.
Clinical Trial
Molecular Weight

301.31

Appearance

Solid

Formula

C15H20NNaO4
CAS No.
SMILES

O=C(O[Na])CCCCCCCNC(C1=CC=CC=C1O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (331.88 mM; Need ultrasonic)

H2O : 100 mg/mL (331.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3188 mL 16.5942 mL 33.1884 mL
5 mM 0.6638 mL 3.3188 mL 6.6377 mL
10 mM 0.3319 mL 1.6594 mL 3.3188 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.72%

COA (243 KB) HNMR (116 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Salcaprozate203787-91-1SNACOthersabsorptionpromoterdeliverytranscellularpermeationacrosslipophilicitynon-covalentmacromoleculecomplexationInhibitorinhibitorinhibit

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