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Salcaprozate sodium (Synonyms: SNAC)

Cat. No.: HY-114299
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Salcaprozate sodium (SNAC) is an oral absorption promoter, and it as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation.

For research use only. We do not sell to patients.

Salcaprozate sodium Chemical Structure

Salcaprozate sodium Chemical Structure

CAS No. : 203787-91-1

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Description

Salcaprozate sodium (SNAC) is an oral absorption promoter, and it as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2].

In Vitro

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL[3].
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution[3].

In Vivo

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats[3].
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident[1].
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d[1].

Animal Model: Sprague-Dawley rats (6-7 weeks)[1]
Dosage: 2000 mg/kg/d
Administration: Oral gavage for 13 weeks
Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.
Molecular Weight

301.31

Formula

C₁₅H₂₀NNaO₄

CAS No.

203787-91-1

SMILES

O=C(O[Na])CCCCCCCNC(C1=CC=CC=C1O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SalcaprozateSNACOthersabsorptionpromoterdeliverytranscellularpermeationacrosslipophilicitynon-covalentmacromoleculecomplexationInhibitorinhibitorinhibit

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Salcaprozate sodium
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HY-114299
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