SAMe-1,4-Butanedisulfonate

Cat. No.: HY-W105505 Purity: 98.03%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SAMe-1,4-Butanedisulfonate 화학구조

CAS No. : 101020-79-5

사이즈	재고	수량
Powder + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Powder
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of SAMe-1,4-Butanedisulfonate:

SAMe-1,4-Butanedisulfonate-d₃ In-stock

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•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

SAMe-1,4-Butanedisulfonate (30 and 60 mg/kg/day, i.m) increases the thickness and cell density of lesioned cartilages in experimental osteoarthritis rabbit^[2].
SAMe-1,4-Butanedisulfonate (60 and 100 mg/kg/day, i.m) protects from liver injury induced by d-galactosamine in rats^[3].
SAMe-1,4-Butanedisulfonate (10-200 mg/kg, i.p.) shows antidepressant-like effects mice submitted to the forced swimming test (FST) and tail suspension test (TST)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice submitted to the forced swimming test (FST) and tail suspension test (TST)^[4]
Dosage:	10, 255, 50, 100, 200 mg/kg
Administration:	i.p.
Result:	Reduced the immobility time in the FST and reduced the total distance traveled.

분자량

725.79

화학식

C₁₅H₂₃N₆O₅S.C₄H₁₀O₆S₂.1/2C₄H₈O₆S₂

CAS No.

101020-79-5

Appearance

Powder

Color

White to off-white

SMILES

O=S(CCCCS(=O)(O)=O)(O)=O.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](C[S+](CC[C@H](N)C(O)=O)C)O3.O=S(CCCCS(=O)([O-])=O)([O-])=O.[1/2]

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 50 mg/mL (68.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3778 mL	6.8890 mL	13.7781 mL
5 mM	0.2756 mL	1.3778 mL	2.7556 mL
10 mM	0.1378 mL	0.6889 mL	1.3778 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (6.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (6.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (6.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 98.03%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB) HNMR (137 KB) RP-HPLC (226 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Delle Chiaie R, et al. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002 Nov;76(5):1172S-6S. [Content Brief]

[2]. Barceló HA, et al. Osteoartritis experimental y su evolución bajo tratamiento con S-adenosil-L-metionina (SAMe) [Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine]. Rev Clin Esp. 1990 Jun;187(2):74-8. Spanish. [Content Brief]

[3]. Stramentinoli G, et al. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem Pharmacol. 1978 May 15;27(10):1431-3. [Content Brief]

[4]. Sales AJ, et al. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochem Int. 2023 Jan;162:105442. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3778 mL	6.8890 mL	13.7781 mL	34.4452 mL
	5 mM	0.2756 mL	1.3778 mL	2.7556 mL	6.8890 mL
	10 mM	0.1378 mL	0.6889 mL	1.3778 mL	3.4445 mL
	15 mM	0.0919 mL	0.4593 mL	0.9185 mL	2.2963 mL
	20 mM	0.0689 mL	0.3445 mL	0.6889 mL	1.7223 mL
	25 mM	0.0551 mL	0.2756 mL	0.5511 mL	1.3778 mL
	30 mM	0.0459 mL	0.2296 mL	0.4593 mL	1.1482 mL
	40 mM	0.0344 mL	0.1722 mL	0.3445 mL	0.8611 mL
	50 mM	0.0276 mL	0.1378 mL	0.2756 mL	0.6889 mL
	60 mM	0.0230 mL	0.1148 mL	0.2296 mL	0.5741 mL