2. TGF-beta/Smad
  3. TGF-β Receptor
  4. SB-431542

SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling.

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SB-431542

SB-431542 構造式

CAS 番号 : 301836-41-9

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SB-431542 関連抗体

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TGF-β Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B BMP GDF15

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製品説明

SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3].

IC50 & Target[1]

ALK4

1 μM (IC50)

ALK5

0.75 μM (IC50)

ALK7

2 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HaCaT EC50
172 nM
Compound: 1a, SB-431542
Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA
Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA
[PMID: 20919678]
HEK-293T IC50
0.066 μM
Compound: SB-431542, SB
Inhibition of TGBR2 signaling in human HEK293T cells assessed as inhibition of SMAD activation after 2 to 22 hrs by dual Luciferase Assay
Inhibition of TGBR2 signaling in human HEK293T cells assessed as inhibition of SMAD activation after 2 to 22 hrs by dual Luciferase Assay
[PMID: 23130626]
HepG2 IC50
250 nM
Compound: SB-431542
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay
[PMID: 19914068]
NCI-H1299 IC50
0.5 μM
Compound: 3, SB-431542
Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
Antimigratory activity against human H1299 cells assessed as inhibition of cell migration after 12 to 24 hrs by transwell migration assay
[PMID: 24417479]
Sf9 IC50
1.542 μM
Compound: 1
Inhibition of human recombinant ALK5 phosphorylation expressed in Sf9 cells
Inhibition of human recombinant ALK5 phosphorylation expressed in Sf9 cells
[PMID: 17552507]
Sf9 IC50
67.1 nM
Compound: SB-431542
Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 2 hrs by ADP-Glo assay
Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 2 hrs by ADP-Glo assay
[PMID: 31408333]
体外実験

SB-431542 (GMP) (10 μM; 10 days) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation[1].
SB-431542 (GMP) (10 μM) facilitates directed differentiation into midbrain dopamine neurons (mDA)[2].
SB-431542 (GMP) (3.8 μM) promotes differentiation of hPSCs to multipotent hematopoietic progenitors that arise from SOX17+ hemogenic endothelium in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB-431542 関連抗体

RT-PCR[1]

Cell Line: Human pluripotent stem cells (hPSCs)
Concentration: 10 μM
Incubation Time: 10 days
Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.
分子量

384.39

分子式

C22H16N4O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N
輸送条件

Shipping with dry ice.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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SB-431542 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-431542 (GMP)301836-41-9TGF-β ReceptorTransforming growth factor beta receptorsmidbrain dopamine (mDA)neuronSMADhuman pluripotent stem cells (hPSCs)Inhibitorinhibitorinhibit

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製品名:
SB-431542
製品番号:
HY-10431G
数量:
MCE 日本正規代理店:

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