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Results for "

[MePhe 7 ]NKB

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

5

Peptides

1

Recombinant Proteins

4

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P3862
    [MePhe7]-Neurokinin B

    		Neurokinin Receptor Neurological Disease Endocrinology
    [MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R) .
    [MePhe7]-Neurokinin B
  • HY-P3801
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11)

    DiMe-C7

    		 Neurokinin Receptor Neurological Disease Metabolic Disease
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11)
  • HY-P3927
    [MePhe8,Sar9] Substance P

    [MePhe8-MeGly9] Substance P

    		 Neurokinin Receptor Neurological Disease
    [MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is an analog of Substance P (HY-P0201). Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS .
    [MePhe8,Sar9] Substance P
  • HY-P3847
    Tyr0-Neurokinin B

    Tyr-NKB

    		 Neurokinin Receptor Neurological Disease
    Tyr0-Neurokinin B (Tyr-NKB) is an analogue of Neurokinin B. Tyr0-Neurokinin B can exerts contractions in bladder .
    Tyr0-Neurokinin B
  • HY-116268
    GSK256471

    		Neurokinin Receptor Neurological Disease
    GSK256471 is a non-peptide tachykinin NK3 receptor antagonist with a pKi of 8.9 for the human recombinant NK3 receptor and 8.4 for the guinea pig native receptor. GSK256471 exhibits >100-fold selectivity for NK1 (pKi = 5.2) and NK2 (pKi = 7.3) receptors. GSK256471 noncompetitively inhibits neurokinin B (NKB) (HY-P0242)-induced inositol phosphate accumulation, and this inhibition is irreversible. GSK256471 inhibits wet dog shaking behavior and suppresses dopamine release. GSK256471 could be used to study schizophrenia .
    GSK256471
  • HY-P11429
    [Asp5,6,Me-Phe8] Substance P (5-11)

    		Neurokinin Receptor Metabolic Disease
    [Asp5,6,Me-Phe8] Substance P (5-11) is a tachykinin NK-3 receptor agonist. [Asp5,6,Me-Phe8] Substance P (5-11) reduces alcohol intake in genetically selected alcohol-preferring rats .
    [Asp5,6,Me-Phe8] Substance P (5-11)
  • HY-182423
    RO5328673

    		Neurokinin Receptor Neurological Disease
    RO5328673 is an orally active, blood-brain barrier permeable neurokinin receptor antagonist that effectively targets human NK3 receptors (Ki=0.4 nM, Ka=0.1 nM), human NK2 receptors (Ki=1.1 nM, Ka=0.9 nM), and guinea pig NK3 receptors (Ka=0.1 nM and 0.13 nM). RO5328673 acts as an insurmountable antagonist of NK3 receptors with a slow dissociation rate, while it shows rapid association and dissociation rates at human NK2 receptors. RO5328673 potently inhibits senktide (HY-P0187)-induced enhancement of spontaneous activity in dopaminergic neurons and reverses senktide-induced changes in motor activity of gerbils. RO5328673 is widely applicable to research related to schizophrenia .
    RO5328673

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