[Glp5,(Me)Phe8,Sar9] Substance P (5-11)
Based on 1 Customer Validation
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.
For research use only. We do not sell to patients.
- Purity : 99.61%
- CAS No.: 77128-69-9
- Formula: C43H61N9O9S
- Molecular Weight:880.06
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
![[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3801.gif "Click to View [Glp5,(Me)Phe8,Sar9] Substance P (5-11) Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vivo
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) increases motor activity and induces recovery of addictive agent-seeking behavior in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Sprague-Dawley rats (300-350 g)[1].
-
Dosage:2 µg/side
-
Administration:Inject into the ventral tegmental area; single
-
Result:Selectively activated mesolimbic and mesocortical dopamine metabolism.
-
Animal Model:Male Wistar rats (300-350 g)[2].
-
Dosage:0.5, 1.5, 3 µg/side
-
Administration:Inject into the ventral tegmental area; single
-
Result:Significantly increased locomotor activity when at 3 µg/side.
Chemical Information
-
CAS No. 77128-69-9
-
Appearance Solid
-
Molecular Weight 880.06
-
Formula C43H61N9O9S
-
Color White to off-white
-
Synonyms
DiMe-C7
-
Sequence
pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2
-
Sequence Shortening
pGlp-QF(-Me)F-Sar-LM-NH2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (113.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. [Content Brief]
[2]. Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. [Content Brief]
[3]. Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1363 mL | 5.6814 mL | 11.3629 mL | 28.4072 mL |
| 5 mM | 0.2273 mL | 1.1363 mL | 2.2726 mL | 5.6814 mL | |
| 10 mM | 0.1136 mL | 0.5681 mL | 1.1363 mL | 2.8407 mL | |
| 15 mM | 0.0758 mL | 0.3788 mL | 0.7575 mL | 1.8938 mL | |
| 20 mM | 0.0568 mL | 0.2841 mL | 0.5681 mL | 1.4204 mL | |
| 25 mM | 0.0455 mL | 0.2273 mL | 0.4545 mL | 1.1363 mL | |
| 30 mM | 0.0379 mL | 0.1894 mL | 0.3788 mL | 0.9469 mL | |
| 40 mM | 0.0284 mL | 0.1420 mL | 0.2841 mL | 0.7102 mL | |
| 50 mM | 0.0227 mL | 0.1136 mL | 0.2273 mL | 0.5681 mL | |
| 60 mM | 0.0189 mL | 0.0947 mL | 0.1894 mL | 0.4735 mL | |
| 80 mM | 0.0142 mL | 0.0710 mL | 0.1420 mL | 0.3551 mL | |
| 100 mM | 0.0114 mL | 0.0568 mL | 0.1136 mL | 0.2841 mL |
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) Related Classifications
HY-P3801 Related Classifications
Powered by Bioz