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5-aminoimidazole ribonucleotide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fungal (1) Thymidylate Synthase (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1)

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Fungal	Infection
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-183973

MTXPG5	Thymidylate Synthase	Inflammation/Immunology Cancer
MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a K_i of 0.047 μM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Fungal
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

Host:	Mouse (2)
Reactivity:	Human (2) mouse (1) rat (1) Rat (1) Mouse (1)
Application:	WB FC ICC/IF (1) WB (1)
Isotype:	IgG1 (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85553

	ATIC Antibody (YA5245) 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICARFT; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein PURH; FLJ93545; IMP cyclohydrolase; IMP synthase; IMP synthetase; IMPCHASE; Inosinicase; OK/SW-cl.86; Phosphoribosylaminoimidazolecarboxamide formyltransferase; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PUR9_HUMAN; PURH.	WB	Human, Mouse, Rat
	ATIC Antibody (YA5245) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ATIC.

HY-P810469

	ATIC Antibody (YA9768) ATIC, 5-aminoimidazole-4-Carboxamide ribonucleotide Formyltransferase/IMP Cyclohydrolase, PURH, IMPCHASE, AICARFT, Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase, AICAR Transformylase/Inosine Monophosphate Cyclohydrolase, Bifunctional Purine Biosynthesis Protein ATIC, 5-aminoimidazole-4-Carboxamide-1-Beta-D-ribonucleotide Transformylase/Inosinicase, AICAR Formyltransferase/IMP Cyclohydrolase Bifunctional Enzyme, Epididymis Secretory Sperm Binding Protein Li 70p, Bifunctional Purine Biosynthesis Protein PURH, AICARFT/IMPCHASE, HEL-S-70p, AICAR	WB FC ICC/IF	Human, mouse, rat
	ATIC Antibody (YA9768) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to ATIC.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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5-aminoimidazole ribonucleotide

Inhibitors & Agonists

NaturalProducts

Antibodies

Natural
Products