2. Anti-infection
  3. Fungal
  4. N-Carbamoyl-L-aspartic acid

N-Carbamoyl-L-aspartic acid  (Synonyms: L-Ureidosuccinic acid)

Cat. No.: HY-128425A Purity: 99.83%
COA
SDS
Handling Instructions Technical Support

N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura+ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

N-Carbamoyl-L-aspartic acid

N-Carbamoyl-L-aspartic acid 화학구조

CAS No. : 13184-27-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of N-Carbamoyl-L-aspartic acid:

N-Carbamoyl-L-aspartic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N-Carbamoyl-L-aspartic acid

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura+ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase[1][2].

In Vitro

N-Carbamoyl-L-aspartic acid (25-100 μg/mL, 10 mg/mL; up to 70 hrs) potently inhibits growth of Saccharomyces cerevisiae wild type FL 100, ura2-60, ura4-20, and ure1 strains, while ura1-8, ura3-6, and ura5-5 strains are highly resistant to this inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Carbamoyl-L-aspartic acid Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Saccharomyces cerevisiae strains (wild type FL 100, ura2-60, ura4-20, ure1, ura1-8, ura3-6, ura5-5)
Concentration: 25 μg/mL, 50 μg/mL, 100 μg/mL, 10 mg/mL; 100 μg/mL
Incubation Time: up to 70 hrs; 375 min
Result: Dramatically inhibited growth of wild type FL 100, ura2-60, ura4-20, and ure1 strains, with initial reduced growth rates that returned to normal after 12-20 hrs (depending on concentration).
Matched untreated cell density by 48 hrs with 100 μg/mL treatment.
Showed no concentration-dependent recovery of normal growth rate in ura4-20 strain.
Only slightly or not inhibited ura1-8, ura3-6, and ura5-5 strains.
Created a halo of no growth surrounding ura4-20 streak near ura2-60 lawns, confirming it is the inhibitory enantiomorph.
Showed unimpeded growth of USA-resistant ura2-60 derivative adjacent to ura4-20.
분자량

176.13

화학식

C5H8N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C[C@@H](C(O)=O)NC(N)=O
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : 31.25 mg/mL (177.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6776 mL 28.3881 mL 56.7762 mL
5 mM 1.1355 mL 5.6776 mL 11.3552 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.83%

SDS (393 KB)

COA (247 KB) HNMR (241 KB) LCMS (322 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6776 mL 28.3881 mL 56.7762 mL 141.9406 mL
5 mM 1.1355 mL 5.6776 mL 11.3552 mL 28.3881 mL
10 mM 0.5678 mL 2.8388 mL 5.6776 mL 14.1941 mL
15 mM 0.3785 mL 1.8925 mL 3.7851 mL 9.4627 mL
20 mM 0.2839 mL 1.4194 mL 2.8388 mL 7.0970 mL
25 mM 0.2271 mL 1.1355 mL 2.2710 mL 5.6776 mL
30 mM 0.1893 mL 0.9463 mL 1.8925 mL 4.7314 mL
40 mM 0.1419 mL 0.7097 mL 1.4194 mL 3.5485 mL
50 mM 0.1136 mL 0.5678 mL 1.1355 mL 2.8388 mL
60 mM 0.0946 mL 0.4731 mL 0.9463 mL 2.3657 mL
80 mM 0.0710 mL 0.3549 mL 0.7097 mL 1.7743 mL
100 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4194 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

N-Carbamoyl-L-aspartic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Carbamoyl-L-aspartic acid13184-27-5L-Ureidosuccinic acidFungalcytosineade2 mutantpyrimidine metabolismSaccharomyces cerevisiaeEscherichia colipurine biosynthetic pathwayadeninedihydroorotase5-aminoimidazole ribonucleotideuracilInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
N-Carbamoyl-L-aspartic acid
Cat. No.:
HY-128425A
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.