13184-27-5
Chemical Structure
N-Carbamoyl-L-aspartic acid
Synonym(s): L-Ureidosuccinic acid
- CAS No.: 13184-27-5
- Formula:C5H8N2O5
- Molecular Weight:176.13
IUPAC Name: carbamoyl-L-aspartic acid
InChIKey: HLKXYZVTANABHZ-REOHCLBHSA-N
SMILES: O=C(O)C[C@@H](C(O)=O)NC(N)=O
Biological Activity: N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura+ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Carbamoyl-L-aspartic acid | 99.83% | N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura+ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase. | ||||||||||||||||||||
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References
- [1]. Korch C T, et al. A regulatory interaction between pyrimidine and purine biosyntheses via ureidosuccinic acid[J]. Molecular and General Genetics MGG, 1974, 133(1): 63-75.
- [2]. Cardeilhac P T. A toxic effect of 2-thiouracil on pyrimidine metabolism[J]. Proceedings of the Society for Experimental Biology and Medicine, 1967, 125(3): 692-696.
