2. Apoptosis
  3. Thymidylate Synthase
  4. MTXPG5

MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a Ki of 0.047 μM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis.

For research use only. We do not sell to patients.

MTXPG5

MTXPG5 Chemical Structure

CAS No. : 80801-54-3

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MTXPG5 Related Antibodies

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Description

MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a Ki of 0.047 μM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis[1][2][3].

In Vitro

MTXPG5 can be used as a pharmacodynamic marker in red blood cells to assess the level of methotrexate exposure[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MTXPG5 Related Antibodies
Molecular Weight

970.91

Formula

C40H50N12O17
CAS No.
SMILES

NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MTXPG5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTXPG580801-54-3MTXPG 5MTXPG-5Thymidylate SynthaseDNA synthesisleukaemiahuman pre-B leukaemia Nalm6 cellspro-inflammatory cytokinelymphoblasts5-aminoimidazole-4-carboxamide ribonucleotide transformylaseimmune cell proliferationthymidylate synthaserheumatoid arthritisred blood cellsInhibitorinhibitorinhibit

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