MTXPG5
MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a Ki of 0.047 μM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 80801-54-3
- Formula: C40H50N12O17
- Molecular Weight:970.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MTXPG5 can be used as a pharmacodynamic marker in red blood cells to assess the level of methotrexate exposure[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 80801-54-3
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Molecular Weight 970.91
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Formula C40H50N12O17
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SMILES
NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Buchholz B, et al. Time course of methotrexate polyglutamate formation and degradation in the pre-B-leukaemia cell line Nalm6 and in lymphoblasts from children with leukaemia. Eur J Cancer. 1996 Nov;32A(12):2101-7. [Content Brief]
[2]. Yang Z, et al. Methotrexate polyglutamates. Expert Rev Clin Pharmacol. 2024 Nov;17(11):1025-1037. [Content Brief]
[3]. Meesters RJ, et al. Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry. Rapid Commun Mass Spectrom. 2011;25(20):3063-3070. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MTXPG5 Related Classifications
HY-183973 Related Classifications
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- MTXPG5
- 80801-54-3
- MTXPG 5
- MTXPG-5
- Thymidylate Synthase
- DNA synthesis
- leukaemia
- human pre-B leukaemia Nalm6 cells
- pro-inflammatory cytokine
- lymphoblasts
- 5-aminoimidazole-4-carboxamide ribonucleotide transformylase
- immune cell proliferation
- thymidylate synthase
- rheumatoid arthritis
- red blood cells
- Inhibitor
- inhibitor
- inhibit