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ABT (Standard)

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15531R
    Venetoclax (Standard)

    ABT-199 (Standard); GDC-0199 (Standard); RG7601 (Standard)

    		 Reference Standards Bcl-2 Family Autophagy Cancer
    Venetoclax (Standard) is the analytical standard of Venetoclax. This product is intended for research and analytical applications. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy .
    Venetoclax (Standard)
  • HY-19569R
    Upadacitinib (Standard)
    1 Publications Verification

    ABT-494 (Standard)

    		 Reference Standards JAK Inflammation/Immunology
    Upadacitinib (Standard) is the analytical standard of Upadacitinib. This product is intended for research and analytical applications. Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research .
    Upadacitinib (Standard)
  • HY-10087R
    Navitoclax (Standard)

    ABT-263 (Standard)

    		 Reference Standards Bcl-2 Family Cancer
    Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .
    Navitoclax (Standard)
  • HY-90001R
    Ritonavir (Standard)

    ABT 538 (Standard); RTV (Standard)

    		 Reference Standards HIV Protease HIV SARS-CoV Apoptosis Infection Cancer
    Ritonavir (Standard) is the analytical standard of Ritonavir. This product is intended for research and analytical applications. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM.
    Ritonavir (Standard)
  • HY-50751R
    Linifanib (Standard)

    ABT-869 (Standard); AL-39324 (Standard)

    		 PDGFR VEGFR FLT3 c-Fms c-Kit Autophagy Apoptosis Reference Standards Cancer
    Linifanib (Standard) is the analytical standard of Linifanib. This product is intended for research and analytical applications. Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis .
    Linifanib (Standard)
  • HY-14814R
    Delafloxacin (Standard)

    RX-3341 (Standard); WQ-3034 (Standard); ABT492 (Standard)

    		 Reference Standards Bacterial Antibiotic Infection
    Delafloxacin (Standard) is the analytical standard of Delafloxacin. This product is intended for research and analytical applications. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia .
    Delafloxacin (Standard)
  • HY-14814AR
    Delafloxacin meglumine (Standard)

    ABT492 meglumine (Standard); RX-3341 meglumine (Standard); WQ-3034 meglumine (Standard)

    		 Reference Standards Bacterial Antibiotic Infection
    Delafloxacin (meglumine) (Standard) is the analytical standard of Delafloxacin (meglumine). This product is intended for research and analytical applications. Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].
    Delafloxacin meglumine (Standard)
  • HY-17634R
    Glecaprevir (Standard)

    ABT-493 (Standard)

    		 HCV HCV Protease SARS-CoV Reference Standards Infection
    Glecaprevir (Standard) is the analytical standard of Glecaprevir. This product is intended for research and analytical applications. Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Glecaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 4.09 μM .
    Glecaprevir (Standard)
  • HY-13270R
    ABT-751 (Standard)

    E7010 (Standard)

    		 Microtubule/Tubulin Autophagy Apoptosis Reference Standards Cancer
    ABT-751 (Standard) is the analytical standard of ABT-751. This product is intended for research and analytical applications. ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer .
    ABT-751 (Standard)
  • HY-10129R
    Veliparib (Standard)

    ABT-888 (Standard)

    		 Reference Standards PARP Autophagy Cancer
    Veliparib (Standard) is the analytical standard of Veliparib. This product is intended for research and analytical applications. Veliparib (ABT-888) is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively .
    Veliparib (Standard)
  • HY-14739R
    Choline Fenofibrate (Standard)

    ABT-335 (Standard)

    		 Reference Standards PPAR COX Cardiovascular Disease
    Choline Fenofibrate (Standard) is the analytical standard of Choline Fenofibrate. This product is intended for research and analytical applications. Choline Fenofibrate (ABT-335), a choline salt of Fenofibric acid (HY-B0760), releases free Fenofibric acid in the gastrointestinal tract. Fenofibric acid is a PPAR activator with antihyperlipidemic effect .
    Choline Fenofibrate (Standard)
  • HY-13998R
    Dasabuvir (Standard)

    ABT-333 (Standard)

    		 Reference Standards HCV DNA/RNA Synthesis Infection
    Dasabuvir (Standard) is the analytical standard of Dasabuvir. This product is intended for research and analytical applications. Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively .
    Dasabuvir (Standard)
  • HY-14588R
    Lopinavir (Standard)

    ABT-378 (Standard)

    		 Reference Standards HIV HIV Protease SARS-CoV Infection Cancer
    Lopinavir (Standard) is the analytical standard of Lopinavir. This product is intended for research and analytical applications. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 14.2 μM .
    Lopinavir (Standard)
  • HY-12594R
    Paritaprevir (Standard)

    ABT-450 (Standard); Veruprevir (Standard)

    		 HCV Protease HCV SARS-CoV Reference Standards Infection
    Paritaprevir (Standard) is the analytical standard of Paritaprevir. This product is intended for research and analytical applications. Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) .
    Paritaprevir (Standard)
  • HY-13997R
    Ombitasvir (Standard)

    ABT-267 (Standard)

    		 HCV Reference Standards Infection
    Ombitasvir (Standard) is the analytical standard of Ombitasvir. This product is intended for research and analytical applications. Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a.
    Ombitasvir (Standard)
  • HY-103389R
    1-Aminobenzotriazole (Standard)

    ABT (Standard); 3-Aminobenzotriazole (Standard)

    		 Reference Standards Cytochrome P450 Cancer
    1-Aminobenzotriazole (Standard) is the analytical standard of 1-Aminobenzotriazole. This product is intended for research and analytical applications. 1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 (P450).
    1-Aminobenzotriazole (Standard)
  • HY-103161R
    ABT-702 dihydrochloride (Standard)

    		Reference Standards Adenosine Kinase Inflammation/Immunology
    ABT-702 dihydrochloride (Standard) is the analytical standard of ABT-702 dihydrochloride (HY-103161). This product is intended for research and analytical applications. ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC50=1.7 nM).
    ABT-702 dihydrochloride (Standard)
  • HY-105170BR
    ABT-418 hydrochloride (Standard)

    		Reference Standards nAChR Neurological Disease
    ABT-418 hydrochloride (Standard) is the analytical standard of ABT-418 hydrochloride (HY-105170B). This product is intended for research and analytical applications. ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease .
    ABT-418 hydrochloride (Standard)
  • HY-101634R
    ABT-072 (Standard)

    		HCV Reference Standards Infection
    ABT-072 (Standard) is the analytical standard of ABT-072 (HY-101634). This product is intended for research and analytical applications. ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM) .
    ABT-072 (Standard)
  • HY-103409R
    ABT-724 trihydrochloride (Standard)

    		Reference Standards Dopamine Receptor Neurological Disease
    ABT-724 trihydrochloride (Standard) is the analytical standard of ABT-724 trihydrochloride (HY-103409). This product is intended for research and analytical applications. ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile .
    ABT-724 trihydrochloride (Standard)
  • HY-10635AR
    (S)-ABT-102 (Standard)

    		TRP Channel Reference Standards Inflammation/Immunology Cancer
    (S)-ABT-102 (Standard) is the analytical standard of (S)-ABT-102 (HY-10635A). This product is intended for research and analytical applications. (S)-ABT-102 is a TRPV1 Antagonist, with an IC50 of 123 nM. (S)-ABT-102 has analgesic activity .
    (S)-ABT-102 (Standard)
  • HY-101634AR
    ABT-072 potassium trihydrate (Standard)

    		HCV Reference Standards Infection
    ABT-072 (potassium trihydrate) (Standard) is the analytical standard of ABT-072 (potassium trihydrate) (HY-101634A). This product is intended for research and analytical applications. ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM) .
    ABT-072 potassium trihydrate (Standard)
  • HY-109001R
    Alicapistat (Standard)

    ABT-957 (Standard)

    		 Reference Standards Proteasome Neurological Disease
    Alicapistat (Standard) is the analytical standard of Alicapistat (HY-109001). This product is intended for research and analytical applications. Alicapistat (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) . Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM .
    Alicapistat (Standard)
  • HY-10130R
    Veliparib dihydrochloride (Standard)

    ABT-888 dihydrochloride (Standard)

    		 PARP Reference Standards Autophagy Cancer
    Veliparib (dihydrochloride) (Standard) is the analytical standard of Veliparib (dihydrochloride) (HY-10130). This product is intended for research and analytical applications. Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.
    Veliparib dihydrochloride (Standard)

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