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Results for "

Argonaute 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SHP1 (1) STAT (1)
By Research Areas:	Cancer (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119024

BCI-137	SHP1 STAT	Cancer
BCI-137 is a Argonaute 2 (AGO2) inhibitor. By inhibiting AGO2 function, reducing PTPN6/SHP-1 protein levels and enhancing STAT1 phosphorylation, BCI-137 restores the sensitivity of tumor cells to IFN-γ. BCI-137 effectively enhances the recruitment, activation and cytotoxicity of CD8 ⁺ T cells. BCI-137 exerts a synergistic effect with anti-PD-1 antibodies and significantly reduces tumor volume in preclinical mouse models. BCI-137 exhibits favorable safety profiles and does not cause significant weight loss or death in mice. BCI-137 can be used in research related to bladder cancer, colorectal cancer, melanoma and other related fields .

Species:	Human (1) Mouse (2)
Tag:	His (3)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74423

	*AGO2/Argonaute-2* Protein, Mouse (sf9, His)** Protein Argonaute-2; Argonaute2; mAgo2; eIF-2C 2; Eif2c2	Mouse	Sf9 insect cells
	The AGO2/Argonaute-2 protein is essential for RNA-mediated gene silencing via the RNA-induced silencing complex (RISC). "Minimal RISC" involves AGO2 binding to a guide RNA, such as microRNA (miRNA) or short interfering RNA (siRNA), which guides RISC for silencing with complementary mRNA. AGO2/Argonaute-2 Protein, Mouse (sf9, His) is the recombinant mouse-derived AGO2/Argonaute-2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P74423Y

	*AGO2/Argonaute-2* Protein, Mouse (sf9, His, solution)** Protein Argonaute-2; Argonaute2; mAgo2; eIF-2C 2; Eif2c2	Mouse	Sf9 insect cells
	The AGO2/Argonaute-2 protein is critical for RNA-mediated silencing complex (RISC)-mediated gene silencing. In "minimal RISC," AGO2 binds to short guide RNAs, such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), to guide RISC for silencing with complementary mRNAs. AGO2/Argonaute-2 Protein, Mouse (sf9, His, solution) is the recombinant mouse-derived AGO2/Argonaute-2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P72835

	*AGO2/Argonaute-2* Protein, Human (sf9, His)** Protein Argonaute-2; hAgo2; eIF-2C 2; PPD; AGO2; EIF2C2	Human	Sf9 insect cells
	The AGO2/Argonaute-2 protein is critical for RNA-mediated silencing complex (RISC)-mediated gene silencing.In "minimal RISC," AGO2 binds to short guide RNAs, such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), to guide RISC for silencing with complementary mRNAs.AGO2/Argonaute-2 Protein, Human (sf9, His) is the recombinant human-derived AGO2/Argonaute-2 protein, expressed by Sf9 insect cells , with N-His, N-10*His labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (2) Mouse (3)
Application:	IHC-P (3) ICC/IF (3) IP (3) WB (3) FC (2) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

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HY-P86098

	Argonaute 2 Antibody (YA5790)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Argonaute 2 Antibody (YA5790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Argonaute 2.

HY-P80441

	Argonaute 2 Antibody (YA612)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
	Argonaute 2 Antibody (YA612) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Argonaute 2.

HY-P80546

	Argonaute 2 Antibody Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Argonaute 2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Argonaute 2.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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