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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

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B7-H4/VTCN1 Antibody

" in MedChemExpress (MCE) Product Catalog:

標的別:	ADC Antibody (1) CD276/B7-H3 (2) CD3 (1)
研究分野別:	Cancer (3) Inflammation/Immunology (1)

阻害剤およびアゴニスト

阻害性抗体

抗体

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) Antibody-Oligonucleotide Conjugates (AOCs) ADC Linker PROTAC-Linker Conjugates for PAC

製品番号	製品名	Target	研究分野	構造式

HY-P991703

Mocertatug GSK5733584 Antibody; HS-20089 Antibody; hu2F7	CD276/B7-H3	Cancer
Mocertatug (GSK5733584 antibody) is a humanized IgG1κ antibody targeting *B7-H4/VTCN1*. Mocertatug can be used to construct ADCs, such as Mocertatug Rezetecan (HY-185280) .

HY-P990059

Puxitatug INT-016; AZD8205 Antibody	ADC Antibody CD276/B7-H3	Cancer
Puxitatug (INT-016; AZD8205 Antibody) is a monoclonal antibody targeting *VTCN1/B7-H4. Puxitatug can be used to synthesize antibody*-drug conjugates (ADCs), such as Puxitatug samrotecan (HY-171689), which can be applied to various solid tumors. Puxitatug can also be used for researching adjuvant therapies for gastric cancer .

HY-P990953

Zubotamig Gen1047	CD3	Cancer
Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of *B7H4*-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of *B7H4*-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer) .

製品番号	製品名	Target	研究分野	Image

HY-P991703

Mocertatug GSK5733584 Antibody; HS-20089 Antibody; hu2F7	CD276/B7-H3	Cancer
Mocertatug (GSK5733584 antibody) is a humanized IgG1κ antibody targeting *B7-H4/VTCN1*. Mocertatug can be used to construct ADCs, such as Mocertatug Rezetecan (HY-185280) .

HY-P990059

Puxitatug INT-016; AZD8205 Antibody	ADC Antibody CD276/B7-H3	Cancer
Puxitatug (INT-016; AZD8205 Antibody) is a monoclonal antibody targeting *VTCN1/B7-H4. Puxitatug can be used to synthesize antibody*-drug conjugates (ADCs), such as Puxitatug samrotecan (HY-171689), which can be applied to various solid tumors. Puxitatug can also be used for researching adjuvant therapies for gastric cancer .

HY-P990341

Anti-B7-H4/VTCN1 Antibody	阻害性抗体	Inflammation/Immunology
Anti-B7-H4/VTCN1 Antibody is a CHO-expressed human antibody that targets *B7-H4/VTCN1. The Anti-B7-H4/VTCN1* Antibody contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-B7-H4/VTCN1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990953

Zubotamig Gen1047	CD3	Cancer
Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of *B7H4*-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of *B7H4*-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer) .

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P810493

	B7H4 Antibody (YA9786) B7H4, UNQ659/PRO1291, VTCN1, V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7h.5, Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7-H4	WB, IHC-F, IHC-P, ICC/IF	Human
	B7H4 Antibody (YA9786) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to B7H4.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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