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BIN2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Atg4 (1) Autophagy (1) Bacterial (1) Cathepsin (1) Cholinesterase (ChE) (1) Complement System (1) Histone Demethylase (1) Monoamine Oxidase (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Phospholipase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

10

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

PDE4B-IN-2	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC₅₀ of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC₅₀=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects .

BIN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BIN2 Human Pre-designed siRNA Set A contains three designed siRNAs for BIN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BIN2 Human Pre-designed siRNA Set A BIN2 Human Pre-designed siRNA Set A

Factor B-IN-2	Complement System	Inflammation/Immunology
Factor B-IN-2 (Example 1 target compound) is a potent complement factor B inhibitor, with an IC₅₀ of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity .

Dual AChE-MAO B-IN-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Dual AChE-MAO B-IN-2 is a potent AChE and MAO B dual inhibitor with IC₅₀s of 0.12 µM and 0.01 µM for b>AChE and MAO B, respectively. Dual AChE-MAO B-IN-2 has the potential for the research of Alzheimer’s disease .

DNA gyrase B-IN-2	Bacterial	Infection
DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC₅₀ < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .

KDM2B-IN-2	Histone Demethylase	Inflammation/Immunology Cancer
KDM2B-IN-2, a potent histone demethylase (kdm2b) inhibitor with an IC₅₀ of 0.021 μM in a KDM2B TR-FRET assay. KDM2B-IN-2 can be used for hyperproliferative diseases research .

HY-137175A

CDC25B-IN-2

Phosphatase Cancer

CDC25B-IN-2 is a potent cdc25B inhibitor .

NaPi2b-IN-2	Others	Others
NaPi2b-IN-2 (compound 5) is a potent inhibitor of sodium-dependent transport protein 2b (SLC34A2, NaPi2b), with an IC₅₀ of 38 nM for human NaPi2b. NaPi2b-IN-2 can be used for the research of hyperphosphatemia .

HY-100462

PTP1B-IN-2

3 Publications Verification

Phosphatase Metabolic Disease

PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

Atg4B-IN-2	Atg4 Cathepsin Phospholipase Autophagy	Cancer
Atg4B-IN-2 is a potent competitive Atg4B inhibitor with K_i value of 3.1 μM, also possesses declining *PLA₂* inhibitory potency, IC₅₀s of 11 μM and 3.5 μM for Atg4B and PLA₂, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition .

Cat. No.	Compare	Product Name	Species	Source

	BIN2 Protein, Human (His) rHuBIN2, His; Bridging Integrator 2; Breast Cancer-Associated Protein 1; BIN2; BRAP1	Human	E. coli
	BIN2 Protein, Human (His) is a recombinant human bridging integrator 2 (BIN2) with a His tag.

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