2. Epigenetics
  3. Histone Demethylase
  4. KDM2B-IN-2

KDM2B-IN-2, a potent histone demethylase (kdm2b) inhibitor with an IC50 of 0.021 μM in a KDM2B TR-FRET assay. KDM2B-IN-2 can be used for hyperproliferative diseases research.

For research use only. We do not sell to patients.

KDM2B-IN-2 Chemical Structure

KDM2B-IN-2 Chemical Structure

CAS No. : 1965248-01-4

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 198 In-stock
Solution
10 mM * 1 mL in DMSO USD 198 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 280 In-stock
25 mg USD 520 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

KDM2B-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

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  • Purity & Documentation

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Description

KDM2B-IN-2, a potent histone demethylase (kdm2b) inhibitor with an IC50 of 0.021 μM in a KDM2B TR-FRET assay. KDM2B-IN-2 can be used for hyperproliferative diseases research[1].

IC50 & Target

KDM2B

0.021 μM (IC50)

Molecular Weight

430.59

Formula

C21H26N4O2S2
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=S(C1=CC=C(C2=CSC=C2)C=C1)(N3C(N4CCN(C5CCC5)CC4)=NCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (72.57 mM; ultrasonic and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3224 mL 11.6120 mL 23.2239 mL
5 mM 0.4645 mL 2.3224 mL 4.6448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3224 mL 11.6120 mL 23.2239 mL 58.0599 mL
5 mM 0.4645 mL 2.3224 mL 4.6448 mL 11.6120 mL
10 mM 0.2322 mL 1.1612 mL 2.3224 mL 5.8060 mL
15 mM 0.1548 mL 0.7741 mL 1.5483 mL 3.8707 mL
20 mM 0.1161 mL 0.5806 mL 1.1612 mL 2.9030 mL
25 mM 0.0929 mL 0.4645 mL 0.9290 mL 2.3224 mL
30 mM 0.0774 mL 0.3871 mL 0.7741 mL 1.9353 mL
40 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4515 mL
50 mM 0.0464 mL 0.2322 mL 0.4645 mL 1.1612 mL
60 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.9677 mL
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KDM2B-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDM2B-IN-21965248-01-4Histone DemethylaseKDM2Bhyperproliferative diseasecancerstrokediabeteshepatomegalycardiovascular diseaseInhibitorinhibitorinhibit

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