Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
BTK-IN-10
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "BTK-IN-10" in MCE Product Catalog:
Research Areas:
PTD10 is a selective and potent BTK PROTAC degrader (DC50 = 0.5 nM, KD = 2.28 nM). PTD10 can recruit cereblon (CRBN) E3 ligase and form a ternary complex with BTK, thereby mediating the ubiquitination and proteasome-dependent degradation of BTK. PTD10 inhibits cancer cells proliferation, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 potently inhibits the BCR, AKT and NF-κB signaling pathway. PTD10 can be used for researches of B-cell malignancies and autoimmune disease .
Cat. No.: HY-160966
CAS No.: 2988804-46-0
Synonyms: PROTAC BTK Degrader-10
Research Areas:
Omtebrutideg (PROTAC BTK Degrader-10) (Example 1P) is a PROTAC degrader for BTK. Omtebrutideg can be used for research of chronic lymphocytic leukemia (CLL) .
Cat. No.: HY-168302
Research Areas:
BTK ligand 10 is the ligand of BTK. BTK ligand 10 can be used to synthesize NX-2127 (HY-153220) .
Target:
Research Areas:
BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment .
Cat. No.: HY-W392857
CAS No.: 1433849-58-1
Target:
Research Areas:
(S)-NH2-Pyridine-piperazine(Me)-Boc is a PROTAC Linker that can be used to synthesize PROTAC BTK Degrader-10 (HY-160966) .
Cat. No.: HY-W733176
CAS No.: 2758531-98-3
Target:
Research Areas:
E3 ligase Ligand 50 is the ligand for E3 ligase Cereblon. E3 ligase Ligand 50 can be used for synthesis of PROTAC BTK Degrader-10 (HY-160966) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
