PROTAC BTK Degrader-10
Based on 1 Customer Validation
PROTAC BTK Degrader-10 (Example 1P) is a PROTAC degrader for BTK. PROTAC BTK Degrader-10 can be used for research of chronic lymphocytic leukemia (CLL).
(Pink: Btk ligand (HY-170758); Blue: Cereblon ligand (HY-W733176); Black: linker (HY-W392857)).
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 2988804-46-0
- Formula: C42H49N11O4
- Molecular Weight:771.91
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Protein Kinase Compound Library
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High-Throughput Bioactive Compound Library
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All PROTACs Isoforms
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Biological Activity
Chemical Information
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CAS No. 2988804-46-0
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Appearance Solid
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Molecular Weight 771.91
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Formula C42H49N11O4
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Color Light yellow to yellow
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SMILES
CC1=C([C@H](NC(C2=NC(C(C)(C)C)=NO2)=O)C)C=CC(C3=NC=NC(NC4=CC=C(C=N4)N5[C@@H](C)CN(CCC6=CC=C(C=C6)N7C(NC(CC7)=O)=O)CC5)=C3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (129.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (264 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2955 mL | 6.4774 mL | 12.9549 mL | 32.3872 mL |
| 5 mM | 0.2591 mL | 1.2955 mL | 2.5910 mL | 6.4774 mL | |
| 10 mM | 0.1295 mL | 0.6477 mL | 1.2955 mL | 3.2387 mL | |
| 15 mM | 0.0864 mL | 0.4318 mL | 0.8637 mL | 2.1591 mL | |
| 20 mM | 0.0648 mL | 0.3239 mL | 0.6477 mL | 1.6194 mL | |
| 25 mM | 0.0518 mL | 0.2591 mL | 0.5182 mL | 1.2955 mL | |
| 30 mM | 0.0432 mL | 0.2159 mL | 0.4318 mL | 1.0796 mL | |
| 40 mM | 0.0324 mL | 0.1619 mL | 0.3239 mL | 0.8097 mL | |
| 50 mM | 0.0259 mL | 0.1295 mL | 0.2591 mL | 0.6477 mL | |
| 60 mM | 0.0216 mL | 0.1080 mL | 0.2159 mL | 0.5398 mL | |
| 80 mM | 0.0162 mL | 0.0810 mL | 0.1619 mL | 0.4048 mL | |
| 100 mM | 0.0130 mL | 0.0648 mL | 0.1295 mL | 0.3239 mL |
PROTAC BTK Degrader-10 Related Classifications
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