1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. BTK inhibitor 10

BTK inhibitor 10 

Cat. No.: HY-125997
Handling Instructions

BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment.

For research use only. We do not sell to patients.

BTK inhibitor 10 Chemical Structure

BTK inhibitor 10 Chemical Structure

CAS No. : 2241732-30-7

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Description

BTK inhibitor 10 is a potent and orally active Bruton kinase (BTK) inhibitor, extracted from patent WO2018145525, example 33. BTK inhibitor 10 has a potential for rheumatoid arthritis treatment[1].

IC50 & Target

IC50: Bruton kinase (BTK)[1]

In Vivo

BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms in CIA mice. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. After 21 days’ oral treatment, BTK030 reduces the arthritic score to 3.62 while the control group shows a value of 8.33[1].

Animal Model: DBA/1J mice injected with collagen as a CIA model[1]
Dosage: 30 mg/kg
Administration: oral gavage; 21 days; once daily
Result: Decreased arthritis scores significantly when it compares to control group.
Molecular Weight

441.48

Formula

C₂₅H₂₃N₅O₃

CAS No.

2241732-30-7

SMILES

C=CC(NC1=CC=CC(OC2=C3C(NC(C4=CC=C(N5CCOCC5)C=C4)=C3)=NC=N2)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BTK inhibitor 10BTK inhibitor10BTK inhibitor-10BtkBruton tyrosine kinaseBTKrheumatoidarthritisCIAInhibitorinhibitorinhibit

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BTK inhibitor 10
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