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Results for "

DGAT2 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (17) Endogenous Metabolite (1) Reference Standards (2)
By Research Areas:	Cardiovascular Disease (3) Inflammation/Immunology (3) Metabolic Disease (15) Neurological Disease (1)
Oligonucleotides:	Antisense Oligonucleotides (4)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108341A

PF-06424439 methanesulfonate Maximum Cited Publications 25 Publications Verification	Acyltransferase	Metabolic Disease
PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM . PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

HY-108341

PF-06424439 Maximum Cited Publications 25 Publications Verification	Acyltransferase	Metabolic Disease
PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM . PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

HY-32219

T863 10+ Cited Publications	Acyltransferase	Metabolic Disease
T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC₅₀ of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells .

HY-156259

PF-07202954	Acyltransferase	Inflammation/Immunology
PF-07202954 is an orally active, highly selective *DGAT2* inhibitor with an IC₅₀ of 10 nM against human *DGAT2* and an IC₅₀ of 17 nM against rat *DGAT2. PF-07202954 reduces triglyceride synthesis, decreases hepatic triglyceride content and plasma triglyceride levels, inhibits* de novo lipogenesis, and suppresses the hepatic SREBP signaling pathway as well as the expression of SREBP target genes. PF-07202954 is applicable to research related to non-alcoholic steatohepatitis .

HY-110381

JNJ-DGAT2-A	Acyltransferase	Metabolic Disease
JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis .

HY-169499

(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid	Acyltransferase	Metabolic Disease
(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid is an intermediate in the synthesis of the diacylglycerol acyltransferase 2 (DGAT-2) inhibitor Ervogastat.

HY-159698A

IONIS-DGAT 2Rx sodium ISIS 484137 sodium; ION-224 sodium	Acyltransferase	Cardiovascular Disease
IONIS-DGAT 2Rx (ION-224) sodium is a *DGAT2* inhibitor, which is promising for research of atherosclerosis .

HY-23199

H2-003	Acyltransferase	Metabolic Disease
H2-003 is a diacylglycerol acyltransferase *DGAT2* inhibitor with an IC₅₀ value of 7.4 μM against human targets. H2-003 reduces triacylglycerol biosynthesis and inhibits lipid droplet formation. H2-003 can be used in studies related to hepatic steatosis and insulin resistance .

HY-138942

PF-06427878	Acyltransferase	Metabolic Disease Inflammation/Immunology
PF-06427878 is an orally active, selective liver-targeted diacylglycerol acyltransferase 2 (DGAT2) inhibitor with IC₅₀s of 99 nM and 202 nM for human and rat DGAT2, respectively. PF-06427878 shows greater than 470-fold selectivity for DGAT2 over DGAT1, MGAT1, MGAT2 and MGAT3. PF-06427878 can improve liver steatosis and function. PF-06427878 can be used for the study of nonalcoholic fatty liver diseases .

HY-159698

IONIS-DGAT 2Rx ISIS 484137; ION-224	Acyltransferase	Cardiovascular Disease
IONIS-DGAT 2Rx (ION-224) is a *DGAT2* inhibitor, which is promising for research of atherosclerosis .

HY-145624

Obeversen ION-769357	Acyltransferase	Metabolic Disease
Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease .

HY-162854

Diacylglycerol acyltransferase inhibitor-2	Acyltransferase	Metabolic Disease
Diacylglycerol acyltransferase inhibitor-2 (Example 8) is an inhibitor of Diacylglycerol Acyl Transferase 2 (DGAT2) with an IC₅₀ value of 3.7 nM .

HY-162978

DGAT2-IN-3	Acyltransferase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
DGAT2-IN-3 (compound 9) is a *DGAT2* inhibitor, with IC₅₀ of 0.4 nM. DGAT2-IN-3 can be used in the research of steatohepatitis, diabetes and cardiovascular diseases .

HY-145624A

Obeversen sodium ION-769357 sodium	Acyltransferase	Metabolic Disease
Obeversen sodium is an antisense oligonucleotide that inhibits the synthesis of Diacylglycerol acyltransferase 2 (DGAT-2). Obeversen sodium can be used in the research of nonalcoholic fatty liver disease .

HY-118386

H2-005	Endogenous Metabolite	Metabolic Disease
H2-005 is a compound that selectively inhibits diacylglycerol acyltransferase 2 (DGAT2) and has the activity to inhibit triacylglycerol synthesis in hepatocytes and preadipocytes. H2-005 significantly reduces triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. H2-005 exhibits specific inhibitory activity in DGAT2-overexpressing HEK293 cells. H2-005 almost completely inhibits lipid droplet formation in 3T3-L1 cells when co-treated with a DGAT1 inhibitor. H2-005 will contribute to DGAT2-related lipid metabolism research and the development of drugs to inhibit metabolic diseases .

HY-108341R

PF-06424439 (Standard)	Reference Standards Acyltransferase	Metabolic Disease
PF-06424439 (Standard) is the analytical standard of PF-06424439 (HY-108341). This product is intended for research and analytical applications. PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM . PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

HY-108341AR

PF-06424439 methanesulfonate (Standard)	Reference Standards Acyltransferase	Metabolic Disease
PF-06424439 methanesulfonate (Standard) is the analytical standard of PF-06424439 (methanesulfonate) (HY-108341A). This product is intended for research and analytical applications. PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM . PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

HY-153507

DGAT1-IN-4	Acyltransferase	Metabolic Disease
DGAT1-IN-4 is a potent, orally active, and selective *DGAT1* inhibitor with an IC₅₀ of 17 nM. DGAT1-IN-4 exhibits >588-fold selectivity over *DGAT2. DGAT1-IN-4 suppresses intracellular triglyceride synthesis in mouse myoblast cells. DGAT1-IN-4 suppresses body weight gain in diet-induced obese dogs. DGAT*1-IN-4 can be used for the research of obesity .

Cat. No.	Product Name		Classification

HY-159698A

IONIS-DGAT 2Rx sodium ISIS 484137 sodium; ION-224 sodium		Antisense Oligonucleotides
IONIS-DGAT 2Rx (ION-224) sodium is a *DGAT2* inhibitor, which is promising for research of atherosclerosis .

HY-159698

IONIS-DGAT 2Rx ISIS 484137; ION-224		Antisense Oligonucleotides
IONIS-DGAT 2Rx (ION-224) is a *DGAT2* inhibitor, which is promising for research of atherosclerosis .

HY-145624

Obeversen ION-769357		Antisense Oligonucleotides
Obeversen is an antisense oligonucleotide that inhibits the synthesis of diacylglycerol acyltransferase 2 (DGAT-2). Obeversen can be used in the research of nonalcoholic fatty liver disease .

HY-145624A

Obeversen sodium ION-769357 sodium		Antisense Oligonucleotides
Obeversen sodium is an antisense oligonucleotide that inhibits the synthesis of Diacylglycerol acyltransferase 2 (DGAT-2). Obeversen sodium can be used in the research of nonalcoholic fatty liver disease .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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