DGAT1-IN-4
DGAT1-IN-4 is a potent, orally active, and selective DGAT1 inhibitor with an IC50 of 17 nM. DGAT1-IN-4 exhibits >588-fold selectivity over DGAT2. DGAT1-IN-4 suppresses intracellular triglyceride synthesis in mouse myoblast cells. DGAT1-IN-4 suppresses body weight gain in diet-induced obese dogs. DGAT1-IN-4 can be used for the research of obesity.
For research use only. We do not sell to patients.
- CAS No.: 1137671-16-9
- Formula: C29H28N4O4
- Molecular Weight:496.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DGAT1 17 nM (IC50) |
DGAT2 >10 μM (IC50) |
DGAT1-IN-4 (compound 9) (2 h) inhibits intracellular triglyceride synthesis in C2C12 mouse myoblast cells with an IC50 of 151 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DGAT1-IN-4 (5 mg/kg; p.o.; daily; 21 days) reduces high-fat diet-induced body weight gain in dogs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Beagle (male, 7-12 kg)[1]
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Dosage:1 mg/kg
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Administration:i.g.; single dose
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Result:Reduced the incremental area under the curve (AUC0-4ₕ) of plasma triglycerides.
Achieved a statistically significant reduction.
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Animal Model:Beagle fed with a high fat diet[1]
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Dosage:5 mg/kg
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Administration:p.o.; daily; 21 days
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Result:Reduced body weight gain from 25% (vehicle group) to 11.7% over 21 days.
Lowered absolute body weight gain from 2.37 kg (vehicle group) to 1.1 kg.
Showed significant differences in body weight gain from day 13 onward.
Chemical Information
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CAS No. 1137671-16-9
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Molecular Weight 496.57
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Formula C29H28N4O4
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SMILES
O=C(O)C(C)(C)CC=1C=C(C(C2=NC=3C=CC(=CC3N2)C4=NN=C(O4)C=5C=CC(OC)=CC5)=C(C1)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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