1137671-16-9
Chemical Structure
DGAT1-IN-4
- CAS No.: 1137671-16-9
- Formula:C29H28N4O4
- Molecular Weight:496.57
IUPAC Name: 3-(4-(6-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-1H-benzo[d]imidazol-2-yl)-3,5-dimethylphenyl)-2,2-dimethylpropanoic acid
InChIKey: JMHFOGLVAUTEJQ-UHFFFAOYSA-N
SMILES: O=C(O)C(C)(C)CC=1C=C(C(C2=NC=3C=CC(=CC3N2)C4=NN=C(O4)C=5C=CC(OC)=CC5)=C(C1)C)C
Biological Activity: DGAT1-IN-4 is a potent, orally active, and selective DGAT1 inhibitor with an IC50 of 17 nM. DGAT1-IN-4 exhibits >588-fold selectivity over DGAT2. DGAT1-IN-4 suppresses intracellular triglyceride synthesis in mouse myoblast cells. DGAT1-IN-4 suppresses body weight gain in diet-induced obese dogs. DGAT1-IN-4 can be used for the research of obesity[1].
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DGAT1-IN-4 | DGAT1-IN-4 is a potent, orally active, and selective DGAT1 inhibitor with an IC50 of 17 nM. DGAT1-IN-4 exhibits >588-fold selectivity over DGAT2. DGAT1-IN-4 suppresses intracellular triglyceride synthesis in mouse myoblast cells. DGAT1-IN-4 suppresses body weight gain in diet-induced obese dogs. DGAT1-IN-4 can be used for the research of obesity. | |||||||||||||||||||||
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Keywords
