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DNA-dependent protein kinase (DNA-PKcs)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA-PK (3) Apoptosis (1) Autophagy (1) HDAC (1)
By Research Areas:	Cancer (4)

Inhibitors & Agonists

Antibodies

Targets Recommended: DNA-PK

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-142944

DNA-PK-IN-2	DNA-PK	Cancer
DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .

HY-142943

DNA-PK-IN-1	DNA-PK	Cancer
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .

HY-164539

TMU 35435	HDAC Autophagy	Cancer
TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC .

HY-122226

IC-87361	DNA-PK Apoptosis	Cancer
IC-87361 is a DNA-dependent protein kinase (DNA-PKcs) inhibitor with an IC₅₀ of 35 nM, and radiosensitizer. IC-87361 inhibits the catalytic activity of *DNA-PKcs* and blocks non-homologous end joining (NHEJ) DNA double-strand break repair. IC-87361 can be used for the research of lung cancer and melanoma .

Host:	Mouse (3) Rabbit (3)
Reactivity:	Human (6) Rat (2) Mouse (2)
Application:	IHC-P (4) ICC/IF (6) IP (4) IHC-F (1) WB (6) ELISA (1)
Isotype:	IgG (3) IgG1 (1) IgG2b (2)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (4)

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

HY-P81270

	DNA PKcs Antibody (YA957) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	DNA PKcs Antibody (YA957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DNA PKcs.

HY-P81270B

	DNA PKcs Antibody (YA959) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	DNA PKcs Antibody (YA959) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA PKcs.

HY-P86339

	DNA PKcs Antibody (YA6031) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	DNA PKcs Antibody (YA6031) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA PKcs.

HY-P81270A

	DNA PKcs Antibody (YA958) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, ICC/IF, IP	Human
	DNA PKcs Antibody (YA958) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DNA PKcs.

HY-P81270AA

	DNA PKcs Antibody (YA958)(PBS only) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, ICC/IF, IP	Human
	DNA PKcs Antibody (YA958) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to DNA PKcs.

HY-P82078

	Phospho-DNA PKcs (Ser2056) Antibody (YA1823) PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460	WB, IHC-P, ICC/IF	Human
	Phospho-DNA PKcs (Ser2056) Antibody (YA1823) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-DNA PKcs (Ser2056).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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