TMU 35435
TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC.
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- CAS 番号: 2231800-32-9
- 分子式: C22H25N3O3
- 分子量:379.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 2231800-32-9
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分子量 379.45
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分子式 C22H25N3O3
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SMILES
O=C(C1=CC=CC2=C1N=C3C(C)=CC=CC3=C2)NCCCCCCC(NO)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Huiwen Chiu, et al. "A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer." Cancers 11.11 (2019): 1703. [Content Brief]
[2]. Yuanhua Wu, et al. "A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer." Cancer letters 400 (2017): 79-88. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TMU 35435 関連分類
HY-164539 関連分類
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