2231800-32-9
2231800-32-9
Chemical Structure
TMU 35435
- CAS No.: 2231800-32-9
- Formula:C22H25N3O3
- Molecular Weight:379.45
InChIKey: LEBIXRLLMSWGPR-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC2=C1N=C3C(C)=CC=CC3=C2)NCCCCCCC(NO)=O
Biological Activity: TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC[1][2].
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TMU 35435 | TMU 35435 is a histone deacetylase (HDAC) inhibitor. TMU-35435 inhibits the NHEJ pathway through ubiquitination of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). In addition, TMU 35435 enhances radiosensitivity by inducing misfolded protein aggregation and autophagy in TNBC. | |||||||||||||||||||||
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References
- [1]. Huiwen Chiu, et al. "A new histone deacetylase inhibitor enhances radiation sensitivity through the induction of misfolded protein aggregation and autophagy in triple-negative breast cancer." Cancers 11.11 (2019): 1703. [Content Brief]
- [2]. Yuanhua Wu, et al. "A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer." Cancer letters 400 (2017): 79-88. [Content Brief]
